%0 Journal Article
%A Shumilov, Anatoliy
%A Tsai, Ming-Han
%A Schlosser, Yvonne
%A Kratz, Anne-Sophie
%A Bernhardt, Katharina
%A Fink, Susanne
%A Mizani, Tuba
%A Lin, Xiaochen
%A Jauch, Anna
%A Mautner, Josef
%A Kopp-Schneider, Annette
%A Feederle, Regina
%A Hoffmann, Ingrid
%A Delecluse, Henri-Jacques
%T Epstein-Barr virus particles induce centrosome amplification and chromosomal instability.060
%J Nature Communications
%V 8
%@ 2041-1723
%C London
%I Nature Publishing Group
%M DKFZ-2017-00404
%P 14257 -
%D 2017
%X Infections with Epstein-Barr virus (EBV) are associated with cancer development, and EBV lytic replication (the process that generates virus progeny) is a strong risk factor for some cancer types. Here we report that EBV infection of B-lymphocytes (in vitro and in a mouse model) leads to an increased rate of centrosome amplification, associated with chromosomal instability. This effect can be reproduced with virus-like particles devoid of EBV DNA, but not with defective virus-like particles that cannot infect host cells. Viral protein BNRF1 induces centrosome amplification, and BNRF1-deficient viruses largely lose this property. These findings identify a new mechanism by which EBV particles can induce chromosomal instability without establishing a chronic infection, thereby conferring a risk for development of tumours that do not necessarily carry the viral genome.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28186092
%2 pmc:PMC5309802
%R 10.1038/ncomms14257
%U https://inrepo02.dkfz.de/record/119777