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000119777 1001_ $$0P:(DE-He78)6848fb449349189d3fde6a1667392cec$$aShumilov, Anatoliy$$b0$$eFirst author$$udkfz
000119777 245__ $$aEpstein-Barr virus particles induce centrosome amplification and chromosomal instability.060
000119777 260__ $$aLondon$$bNature Publishing Group$$c2017
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000119777 520__ $$aInfections with Epstein-Barr virus (EBV) are associated with cancer development, and EBV lytic replication (the process that generates virus progeny) is a strong risk factor for some cancer types. Here we report that EBV infection of B-lymphocytes (in vitro and in a mouse model) leads to an increased rate of centrosome amplification, associated with chromosomal instability. This effect can be reproduced with virus-like particles devoid of EBV DNA, but not with defective virus-like particles that cannot infect host cells. Viral protein BNRF1 induces centrosome amplification, and BNRF1-deficient viruses largely lose this property. These findings identify a new mechanism by which EBV particles can induce chromosomal instability without establishing a chronic infection, thereby conferring a risk for development of tumours that do not necessarily carry the viral genome.
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000119777 7001_ $$0P:(DE-He78)33beb55034049b5d9833135ad1e0e3d2$$aTsai, Ming-Han$$b1$$udkfz
000119777 7001_ $$0P:(DE-He78)17c613734048909eba90a035b706d39f$$aSchlosser, Yvonne$$b2$$udkfz
000119777 7001_ $$0P:(DE-He78)11bfb09146a8b8651ea33cdad7ec73c4$$aKratz, Anne-Sophie$$b3$$udkfz
000119777 7001_ $$0P:(DE-He78)944cafd16d8f74f63b6b7039c6407dc5$$aBernhardt, Katharina$$b4$$udkfz
000119777 7001_ $$0P:(DE-He78)3877ae274d0271d6bf311bb46539f013$$aFink, Susanne$$b5$$udkfz
000119777 7001_ $$0P:(DE-He78)7f881c2feed7e2cfa3b420552f8d4e22$$aMizani, Tuba$$b6$$udkfz
000119777 7001_ $$0P:(DE-He78)da1a557349f25c641b1a368af5b218a7$$aLin, Xiaochen$$b7$$udkfz
000119777 7001_ $$aJauch, Anna$$b8
000119777 7001_ $$aMautner, Josef$$b9
000119777 7001_ $$0P:(DE-He78)bb6a7a70f976eb8df1769944bf913596$$aKopp-Schneider, Annette$$b10$$udkfz
000119777 7001_ $$0P:(DE-He78)ac9bd330be3905c47d74d99f48793191$$aFeederle, Regina$$b11$$udkfz
000119777 7001_ $$0P:(DE-He78)b97fa0c782a162d952b6197f3b916379$$aHoffmann, Ingrid$$b12$$udkfz
000119777 7001_ $$0P:(DE-He78)25d3c74b949988c637571e696fc04b25$$aDelecluse, Henri-Jacques$$b13$$eLast author$$udkfz
000119777 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/ncomms14257$$gVol. 8, p. 14257 -$$p14257 -$$tNature Communications$$v8$$x2041-1723$$y2017
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