TY  - JOUR
AU  - Shumilov, Anatoliy
AU  - Tsai, Ming-Han
AU  - Schlosser, Yvonne
AU  - Kratz, Anne-Sophie
AU  - Bernhardt, Katharina
AU  - Fink, Susanne
AU  - Mizani, Tuba
AU  - Lin, Xiaochen
AU  - Jauch, Anna
AU  - Mautner, Josef
AU  - Kopp-Schneider, Annette
AU  - Feederle, Regina
AU  - Hoffmann, Ingrid
AU  - Delecluse, Henri-Jacques
TI  - Epstein-Barr virus particles induce centrosome amplification and chromosomal instability.060
JO  - Nature Communications
VL  - 8
SN  - 2041-1723
CY  - London
PB  - Nature Publishing Group
M1  - DKFZ-2017-00404
SP  - 14257 -
PY  - 2017
AB  - Infections with Epstein-Barr virus (EBV) are associated with cancer development, and EBV lytic replication (the process that generates virus progeny) is a strong risk factor for some cancer types. Here we report that EBV infection of B-lymphocytes (in vitro and in a mouse model) leads to an increased rate of centrosome amplification, associated with chromosomal instability. This effect can be reproduced with virus-like particles devoid of EBV DNA, but not with defective virus-like particles that cannot infect host cells. Viral protein BNRF1 induces centrosome amplification, and BNRF1-deficient viruses largely lose this property. These findings identify a new mechanism by which EBV particles can induce chromosomal instability without establishing a chronic infection, thereby conferring a risk for development of tumours that do not necessarily carry the viral genome.
LB  - PUB:(DE-HGF)16
C6  - pmid:28186092
C2  - pmc:PMC5309802
DO  - DOI:10.1038/ncomms14257
UR  - https://inrepo02.dkfz.de/record/119777
ER  -