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@ARTICLE{Shumilov:119777,
      author       = {A. Shumilov$^*$ and M.-H. Tsai$^*$ and Y. Schlosser$^*$ and
                      A.-S. Kratz$^*$ and K. Bernhardt$^*$ and S. Fink$^*$ and T.
                      Mizani$^*$ and X. Lin$^*$ and A. Jauch and J. Mautner and A.
                      Kopp-Schneider$^*$ and R. Feederle$^*$ and I. Hoffmann$^*$
                      and H.-J. Delecluse$^*$},
      title        = {{E}pstein-{B}arr virus particles induce centrosome
                      amplification and chromosomal instability.060},
      journal      = {Nature Communications},
      volume       = {8},
      issn         = {2041-1723},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2017-00404},
      pages        = {14257 -},
      year         = {2017},
      abstract     = {Infections with Epstein-Barr virus (EBV) are associated
                      with cancer development, and EBV lytic replication (the
                      process that generates virus progeny) is a strong risk
                      factor for some cancer types. Here we report that EBV
                      infection of B-lymphocytes (in vitro and in a mouse model)
                      leads to an increased rate of centrosome amplification,
                      associated with chromosomal instability. This effect can be
                      reproduced with virus-like particles devoid of EBV DNA, but
                      not with defective virus-like particles that cannot infect
                      host cells. Viral protein BNRF1 induces centrosome
                      amplification, and BNRF1-deficient viruses largely lose this
                      property. These findings identify a new mechanism by which
                      EBV particles can induce chromosomal instability without
                      establishing a chronic infection, thereby conferring a risk
                      for development of tumours that do not necessarily carry the
                      viral genome.},
      cin          = {F100 / F045 / C060},
      ddc          = {500},
      cid          = {I:(DE-He78)F100-20160331 / I:(DE-He78)F045-20160331 /
                      I:(DE-He78)C060-20160331},
      pnm          = {316 - Infections and cancer (POF3-316)},
      pid          = {G:(DE-HGF)POF3-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28186092},
      pmc          = {pmc:PMC5309802},
      doi          = {10.1038/ncomms14257},
      url          = {https://inrepo02.dkfz.de/record/119777},
}