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@ARTICLE{Schuenke:119782,
      author       = {P. Schuenke$^*$ and D. Paech$^*$ and C. Köhler$^*$ and J.
                      Windschuh$^*$ and P. Bachert$^*$ and M. Ladd$^*$ and H.-P.
                      Schlemmer$^*$ and A. Radbruch$^*$ and M. Zaiss$^*$},
      title        = {{F}ast and {Q}uantitative {T}1ρ-weighted {D}ynamic
                      {G}lucose {E}nhanced {MRI}.},
      journal      = {Scientific reports},
      volume       = {7},
      issn         = {2045-2322},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2017-00409},
      pages        = {42093 -},
      year         = {2017},
      abstract     = {Common medical imaging techniques usually employ contrast
                      agents that are chemically labeled, e.g. with radioisotopes
                      in the case of PET, iodine in the case of CT or paramagnetic
                      metals in the case of MRI to visualize the heterogeneity of
                      the tumor microenvironment. Recently, it was shown that
                      natural unlabeled D-glucose can be used as a nontoxic
                      biodegradable contrast agent in Chemical Exchange sensitive
                      Spin-Lock (CESL) magnetic resonance imaging (MRI) to detect
                      the glucose uptake and potentially the metabolism of tumors.
                      As an important step to fulfill the clinical needs for
                      practicability, reproducibility and imaging speed we present
                      here a robust and quantitative T1ρ-weighted technique for
                      dynamic glucose enhanced MRI (DGE-MRI) with a temporal
                      resolution of less than 7 seconds. Applied to a brain
                      tumor patient, the new technique provided a distinct DGE
                      contrast between tumor and healthy brain tissue and showed
                      the detailed dynamics of the glucose enhancement after
                      intravenous injection. Development of this fast and
                      quantitative DGE-MRI technique allows for a more detailed
                      analysis of DGE correlations in the future and potentially
                      enables non-invasive diagnosis, staging and monitoring of
                      tumor response to therapy.},
      cin          = {E020 / E010},
      ddc          = {000},
      cid          = {I:(DE-He78)E020-20160331 / I:(DE-He78)E010-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28169369},
      pmc          = {pmc:PMC5294399},
      doi          = {10.1038/srep42093},
      url          = {https://inrepo02.dkfz.de/record/119782},
}