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@ARTICLE{Straub:119783,
      author       = {S. Straub$^*$ and F. Laun$^*$ and J. Emmerich$^*$ and B.
                      Jobke$^*$ and H. Hauswald$^*$ and S. Katayama and K.
                      Herfarth and H.-P. Schlemmer$^*$ and M. Ladd$^*$ and C.
                      Ziener$^*$ and D. Bonekamp$^*$ and M. Röthke$^*$},
      title        = {{P}otential of quantitative susceptibility mapping for
                      detection of prostatic calcifications.16},
      journal      = {Journal of magnetic resonance imaging},
      volume       = {45},
      number       = {3},
      issn         = {1053-1807},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2017-00410},
      pages        = {889 - 898},
      year         = {2017},
      abstract     = {To evaluate whether quantitative susceptibility (QSM) may
                      be used as an alternative to computed tomography (CT) to
                      detect calcification in prostate cancer
                      patients.Susceptibility map calculation was performed using
                      3D gradient echo magnetic resonance imaging (MRI) data from
                      26 patients measured at 3T who previously received a
                      planning CT of the prostate. Phase images were unwrapped
                      using Laplacian-based phase unwrapping, the background field
                      was removed with the V-SHARP method, and susceptibility maps
                      were calculated with the iLSQR method. Two blinded readers
                      were asked to identify peri- and intraprostatic
                      calcifications.Average mean and minimum susceptibility
                      values (referenced to iliopsoas muscle) of calcifications
                      were -0.249 ± 0.179 ppm and
                      -0.551 ± 0.323 ppm, and average mean and maximum
                      intensities in CT images were 319 ± 164 HU and
                      679 ± 392 HU. Twenty-one and 17 out of 22 prostatic
                      calcifications were identified using susceptibility maps and
                      magnitude images, respectively, as well as more than half of
                      periprostatic phleboliths depicted by CT. Calcifications in
                      the prostate and its periphery were quantitatively
                      differentiable from noncalcified prostate tissue in CT (mean
                      values for calcifications / for noncalcified tissue: 71 to
                      649 / -1 to 83 HU) and in QSM (mean values for
                      calcifications / for noncalcified tissue: -0.641 to 0.063 /
                      -0.046 to 0.181 ppm). Moreover, there was a significant
                      correlation between susceptibility values and CT image
                      intensities for calcifications (P < 0.004).Prostatic
                      calcifications could be well identified with QSM.
                      Susceptibility maps can be easily obtained from clinical
                      prostate MR protocols that include a 3D gradient echo
                      sequence, rendering it a promising technique for detection
                      and quantification of intraprostatic calcifications.1 J.
                      Magn. Reson. Imaging 2017;45:889-898.},
      cin          = {E020 / E010 / E050},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331 / I:(DE-He78)E010-20160331 /
                      I:(DE-He78)E050-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27418017},
      doi          = {10.1002/jmri.25385},
      url          = {https://inrepo02.dkfz.de/record/119783},
}