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@ARTICLE{FischerKeo:120012,
      author       = {R. Fischer-Kešo$^*$ and S. Breuninger$^*$ and S.
                      Hofmann$^*$ and M. Henn and T. Röhrig and P. Ströbel and
                      G. Stoecklin$^*$ and I. Hofmann$^*$},
      title        = {{P}lakophilins 1 and 3 bind to {FXR}1 and thereby influence
                      the m{RNA} stability of desmosomal proteins.},
      journal      = {Molecular and cellular biology},
      volume       = {34},
      number       = {23},
      issn         = {1098-5549},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {DKFZ-2017-00600},
      pages        = {4244 - 4256},
      year         = {2014},
      abstract     = {Plakophilins 1 and 3 (PKP1/3) are members of the arm repeat
                      family of catenin proteins and serve as structural
                      components of desmosomes, which are important for
                      cell-cell-adhesion. In addition, PKP1/3 occur as soluble
                      proteins outside desmosomes, yet their role in the cytoplasm
                      is not known. We found that cytoplasmic PKP1/3
                      coprecipitated with the RNA-binding proteins FXR1, G3BP,
                      PABPC1, and UPF1, and these PKP1/3 complexes also comprised
                      desmoplakin and PKP2 mRNAs. Moreover, we showed that the
                      interaction of PKP1/3 with G3BP, PABPC1, and UPF1 but not
                      with FXR1 was RNase sensitive. To address the cytoplasmic
                      function of PKP1/3, we performed gain-and-loss-of-function
                      studies. Both PKP1 and PKP3 knockdown cell lines showed
                      reduced protein and mRNA levels for desmoplakin and PKP2.
                      Whereas global rates of translation were unaffected,
                      desmoplakin and PKP2 mRNA were destabilized. Furthermore,
                      binding of PKP1/3 to FXR1 was RNA independent, and both PKP3
                      and FXR1 stabilized PKP2 mRNA. Our results demonstrate that
                      cytoplasmic PKP1/3 are components of mRNA ribonucleoprotein
                      particles and act as posttranscriptional regulators of gene
                      expression.},
      keywords     = {Carrier Proteins (NLM Chemicals) / Desmoplakins (NLM
                      Chemicals) / FXR1 protein, human (NLM Chemicals) / G3BP
                      protein, human (NLM Chemicals) / PABPC1L protein, human (NLM
                      Chemicals) / PKP1 protein, human (NLM Chemicals) / PKP3
                      protein, human (NLM Chemicals) / Plakophilins (NLM
                      Chemicals) / Poly(A)-Binding Proteins (NLM Chemicals) / RNA,
                      Messenger (NLM Chemicals) / RNA-Binding Proteins (NLM
                      Chemicals) / Trans-Activators (NLM Chemicals) / UPF1
                      protein, human (NLM Chemicals)},
      cin          = {A190 / A200},
      ddc          = {570},
      cid          = {I:(DE-He78)A190-20160331 / I:(DE-He78)A200-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25225333},
      pmc          = {pmc:PMC4248750},
      doi          = {10.1128/MCB.00766-14},
      url          = {https://inrepo02.dkfz.de/record/120012},
}