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@ARTICLE{Gillmann:120082,
      author       = {C. Gillmann and O. Jäkel$^*$ and I. Schlampp and C.
                      Karger$^*$},
      title        = {{T}emporal lobe reactions after carbon ion radiation
                      therapy: comparison of relative biological
                      effectiveness-weighted tolerance doses predicted by local
                      effect models {I} and {IV}.15},
      journal      = {International journal of radiation oncology, biology,
                      physics},
      volume       = {88},
      number       = {5},
      issn         = {0360-3016},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2017-00669},
      pages        = {1136 - 1141},
      year         = {2014},
      abstract     = {To compare the relative biological effectiveness
                      (RBE)-weighted tolerance doses for temporal lobe reactions
                      after carbon ion radiation therapy using 2 different
                      versions of the local effect model (LEM I vs LEM IV) for the
                      same patient collective under identical conditions.In a
                      previous study, 59 patients were investigated, of whom 10
                      experienced temporal lobe reactions (TLR) after carbon ion
                      radiation therapy for low-grade skull-base chordoma and
                      chondrosarcoma at Helmholtzzentrum für Schwerionenforschung
                      (GSI) in Darmstadt, Germany in 2002 and 2003. TLR were
                      detected as visible contrast enhancements on T1-weighted MRI
                      images within a median follow-up time of 2.5 years. Although
                      the derived RBE-weighted temporal lobe doses were based on
                      the clinically applied LEM I, we have now recalculated the
                      RBE-weighted dose distributions using LEM IV and derived
                      dose-response curves with Dmax,V-1 cm³ (the RBE-weighted
                      maximum dose in the remaining temporal lobe volume,
                      excluding the volume of 1 cm³ with the highest dose) as an
                      independent dosimetric variable. The resulting RBE-weighted
                      tolerance doses were compared with those of the previous
                      study to assess the clinical impact of LEM IV relative to
                      LEM I.The dose-response curve of LEM IV is shifted toward
                      higher values compared to that of LEM I. The RBE-weighted
                      tolerance dose for a $5\%$ complication probability (TD5)
                      increases from 68.8 ± 3.3 to 78.3 ± 4.3 Gy (RBE) for LEM
                      IV as compared to LEM I.LEM IV predicts a clinically
                      significant increase of the RBE-weighted tolerance doses for
                      the temporal lobe as compared to the currently applied LEM
                      I. The limited available photon data do not allow a final
                      conclusion as to whether RBE predictions of LEM I or LEM IV
                      better fit better clinical experience in photon therapy. The
                      decision about a future clinical application of LEM IV
                      therefore requires additional analysis of temporal lobe
                      reactions in a comparable photon-treated collective using
                      the same dosimetric variable as in the present study.},
      keywords     = {Ions (NLM Chemicals) / Carbon (NLM Chemicals)},
      cin          = {E040},
      ddc          = {610},
      cid          = {I:(DE-He78)E040-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:24661667},
      doi          = {10.1016/j.ijrobp.2013.12.039},
      url          = {https://inrepo02.dkfz.de/record/120082},
}