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@ARTICLE{Pianko:120132,
      author       = {M. J. Pianko and E. Terpos and G. D. Roodman and C. R.
                      Divgi and S. Zweegman and J. Hillengass$^*$ and S. Lentzsch},
      title        = {{W}hole-body low-dose computed tomography and advanced
                      imaging techniques for multiple myeloma bone disease.},
      journal      = {Clinical cancer research},
      volume       = {20},
      number       = {23},
      issn         = {1557-3265},
      address      = {Philadelphia, Pa. [u.a.]},
      publisher    = {AACR},
      reportid     = {DKFZ-2017-00715},
      pages        = {5888 - 5897},
      year         = {2014},
      abstract     = {Detection of lytic bone lesions is crucial in the workup
                      for multiple myeloma and very often dictates the decision to
                      start treatment. Conventional radiography, despite decades
                      of use, is often insufficient for detection of bone disease
                      in multiple myeloma. Modern imaging techniques such as MRI,
                      PET, and CT offer superior detection of myeloma bone disease
                      and extramedullary manifestations of plasma cell dyscrasias.
                      Novel whole-body low-dose computed tomography (WBLDCT)
                      protocols allow for collection of superior image detail of
                      the skeleton at doses of radiation similar to those used for
                      conventional planar radiography. Several studies have shown
                      that WBLDCT has a superior detection rate for lytic bone
                      lesions compared with whole-body X-ray (WBXR), potentially
                      leading to restaging and changes in therapy. MRI and PET
                      provide imaging data important for assessing disease
                      activity and prognostication. Because of several advantages
                      over WBXR, WBLDCT is already the standard imaging technique
                      for use in patients with multiple myeloma in many European
                      institutions. However, the radiographic skeletal survey or
                      WBXR is still the initial study of choice used to screen for
                      myeloma bone disease in many institutions. In this review,
                      we aim to explore the changing landscape of imaging for
                      myeloma bone disease through use of modern imaging
                      techniques.},
      cin          = {E013},
      ddc          = {610},
      cid          = {I:(DE-He78)E013-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25294899},
      doi          = {10.1158/1078-0432.CCR-14-1692},
      url          = {https://inrepo02.dkfz.de/record/120132},
}