%0 Journal Article
%A Poetsch, Anna R
%A Lipka, Daniel
%A Witte, Tania
%A Claus, Rainer
%A Nöllke, Peter
%A Zucknick, Manuela
%A Olk-Batz, Christiane
%A Fluhr, Silvia
%A Dworzak, Michael
%A De Moerloose, Barbara
%A Starý, Jan
%A Zecca, Marco
%A Hasle, Henrik
%A Schmugge, Markus
%A van den Heuvel-Eibrink, Marry M
%A Locatelli, Franco
%A Niemeyer, Charlotte M
%A Flotho, Christian
%A Plass, Christoph
%T RASA4 undergoes DNA hypermethylation in resistant juvenile myelomonocytic leukemia.
%J Epigenetics
%V 9
%N 9
%@ 1559-2308
%C Austin, Tex.
%I Landes Bioscience
%M DKFZ-2017-00729
%P 1252 - 1260
%D 2014
%X Aberrant DNA methylation at specific genetic loci is a key molecular feature of juvenile myelomonocytic leukemia (JMML) with poor prognosis. Using quantitative high-resolution mass spectrometry, we identified RASA4 isoform 2, which maps to chromosome 7 and encodes a member of the GAP1 family of GTPase-activating proteins for small G proteins, as a recurrent target of isoform-specific DNA hypermethylation in JMML (51
%K Protein Isoforms (NLM Chemicals)
%K RASA4 protein, human (NLM Chemicals)
%K ras GTPase-Activating Proteins (NLM Chemicals)
%K PTPN11 protein, human (NLM Chemicals)
%K Protein Tyrosine Phosphatase, Non-Receptor Type 11 (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:25147919
%2 pmc:PMC4169017
%R 10.4161/epi.29941
%U https://inrepo02.dkfz.de/record/120146