TY  - JOUR
AU  - Poetsch, Anna R
AU  - Lipka, Daniel
AU  - Witte, Tania
AU  - Claus, Rainer
AU  - Nöllke, Peter
AU  - Zucknick, Manuela
AU  - Olk-Batz, Christiane
AU  - Fluhr, Silvia
AU  - Dworzak, Michael
AU  - De Moerloose, Barbara
AU  - Starý, Jan
AU  - Zecca, Marco
AU  - Hasle, Henrik
AU  - Schmugge, Markus
AU  - van den Heuvel-Eibrink, Marry M
AU  - Locatelli, Franco
AU  - Niemeyer, Charlotte M
AU  - Flotho, Christian
AU  - Plass, Christoph
TI  - RASA4 undergoes DNA hypermethylation in resistant juvenile myelomonocytic leukemia.
JO  - Epigenetics
VL  - 9
IS  - 9
SN  - 1559-2308
CY  - Austin, Tex.
PB  - Landes Bioscience
M1  - DKFZ-2017-00729
SP  - 1252 - 1260
PY  - 2014
AB  - Aberrant DNA methylation at specific genetic loci is a key molecular feature of juvenile myelomonocytic leukemia (JMML) with poor prognosis. Using quantitative high-resolution mass spectrometry, we identified RASA4 isoform 2, which maps to chromosome 7 and encodes a member of the GAP1 family of GTPase-activating proteins for small G proteins, as a recurrent target of isoform-specific DNA hypermethylation in JMML (51
KW  - Protein Isoforms (NLM Chemicals)
KW  - RASA4 protein, human (NLM Chemicals)
KW  - ras GTPase-Activating Proteins (NLM Chemicals)
KW  - PTPN11 protein, human (NLM Chemicals)
KW  - Protein Tyrosine Phosphatase, Non-Receptor Type 11 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:25147919
C2  - pmc:PMC4169017
DO  - DOI:10.4161/epi.29941
UR  - https://inrepo02.dkfz.de/record/120146
ER  -