% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Poetsch:120146,
      author       = {A. R. Poetsch$^*$ and D. Lipka$^*$ and T. Witte$^*$ and R.
                      Claus$^*$ and P. Nöllke and M. Zucknick$^*$ and C. Olk-Batz
                      and S. Fluhr and M. Dworzak and B. De Moerloose and J.
                      Starý and M. Zecca and H. Hasle and M. Schmugge and M. M.
                      van den Heuvel-Eibrink and F. Locatelli and C. M.
                      Niemeyer$^*$ and C. Flotho$^*$ and C. Plass$^*$},
      title        = {{RASA}4 undergoes {DNA} hypermethylation in resistant
                      juvenile myelomonocytic leukemia.},
      journal      = {Epigenetics},
      volume       = {9},
      number       = {9},
      issn         = {1559-2308},
      address      = {Austin, Tex.},
      publisher    = {Landes Bioscience},
      reportid     = {DKFZ-2017-00729},
      pages        = {1252 - 1260},
      year         = {2014},
      abstract     = {Aberrant DNA methylation at specific genetic loci is a key
                      molecular feature of juvenile myelomonocytic leukemia (JMML)
                      with poor prognosis. Using quantitative high-resolution mass
                      spectrometry, we identified RASA4 isoform 2, which maps to
                      chromosome 7 and encodes a member of the GAP1 family of
                      GTPase-activating proteins for small G proteins, as a
                      recurrent target of isoform-specific DNA hypermethylation in
                      JMML $(51\%$ of 125 patients analyzed). RASA4 isoform 2
                      promoter methylation correlated with clinical parameters
                      predicting poor prognosis (older age, elevated fetal
                      hemoglobin), with higher risk of relapse after hematopoietic
                      stem cell transplantation, and with PTPN11 mutation. The
                      level of isoform 2 methylation increased in relapsed cases
                      after transplantation. Interestingly, most JMML cases with
                      monosomy 7 exhibited hypermethylation on the remaining RASA4
                      allele. The results corroborate the significance of
                      epigenetic modifications in the phenotype of aggressive
                      JMML.},
      keywords     = {Protein Isoforms (NLM Chemicals) / RASA4 protein, human
                      (NLM Chemicals) / ras GTPase-Activating Proteins (NLM
                      Chemicals) / PTPN11 protein, human (NLM Chemicals) / Protein
                      Tyrosine Phosphatase, Non-Receptor Type 11 (NLM Chemicals)},
      cin          = {C010 / C060 / L101 / L601},
      ddc          = {610},
      cid          = {I:(DE-He78)C010-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)L101-20160331 / I:(DE-He78)L601-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:25147919},
      pmc          = {pmc:PMC4169017},
      doi          = {10.4161/epi.29941},
      url          = {https://inrepo02.dkfz.de/record/120146},
}