%0 Journal Article
%A Häuser, Roman
%A Ceol, Arnaud
%A Rajagopala, Seesandra V
%A Mosca, Roberto
%A Siszler, Gabriella
%A Wermke, Nadja
%A Sikorski, Patricia
%A Schwarz, Frank
%A Schick, Matthias
%A Wuchty, Stefan
%A Aloy, Patrick
%A Uetz, Peter
%T A second-generation protein-protein interaction network of Helicobacter pylori.
%J Molecular & cellular proteomics
%V 13
%N 5
%@ 1535-9484
%C Bethesda, Md.
%I The American Society for Biochemistry and Molecular Biology
%M DKFZ-2017-00757
%P 1318 - 1329
%D 2014
%X Helicobacter pylori infections cause gastric ulcers and play a major role in the development of gastric cancer. In 2001, the first protein interactome was published for this species, revealing over 1500 binary protein interactions resulting from 261 yeast two-hybrid screens. Here we roughly double the number of previously published interactions using an ORFeome-based, proteome-wide yeast two-hybrid screening strategy. We identified a total of 1515 protein-protein interactions, of which 1461 are new. The integration of all the interactions reported in H. pylori results in 3004 unique interactions that connect about 70
%K Bacterial Proteins (NLM Chemicals)
%K Proteome (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:24627523
%2 pmc:PMC4014287
%R 10.1074/mcp.O113.033571
%U https://inrepo02.dkfz.de/record/120175