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000120175 041__ $$aeng
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000120175 1001_ $$0P:(DE-HGF)0$$aHäuser, Roman$$b0$$eFirst author
000120175 245__ $$aA second-generation protein-protein interaction network of Helicobacter pylori.
000120175 260__ $$aBethesda, Md.$$bThe American Society for Biochemistry and Molecular Biology$$c2014
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000120175 520__ $$aHelicobacter pylori infections cause gastric ulcers and play a major role in the development of gastric cancer. In 2001, the first protein interactome was published for this species, revealing over 1500 binary protein interactions resulting from 261 yeast two-hybrid screens. Here we roughly double the number of previously published interactions using an ORFeome-based, proteome-wide yeast two-hybrid screening strategy. We identified a total of 1515 protein-protein interactions, of which 1461 are new. The integration of all the interactions reported in H. pylori results in 3004 unique interactions that connect about 70% of its proteome. Excluding interactions of promiscuous proteins we derived from our new data a core network consisting of 908 interactions. We compared our data set to several other bacterial interactomes and experimentally benchmarked the conservation of interactions using 365 protein pairs (interologs) of E. coli of which one third turned out to be conserved in both species.
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000120175 650_7 $$2NLM Chemicals$$aBacterial Proteins
000120175 650_7 $$2NLM Chemicals$$aProteome
000120175 7001_ $$aCeol, Arnaud$$b1
000120175 7001_ $$aRajagopala, Seesandra V$$b2
000120175 7001_ $$aMosca, Roberto$$b3
000120175 7001_ $$aSiszler, Gabriella$$b4
000120175 7001_ $$0P:(DE-He78)a54a388ffb18595b652f5cff0cef670b$$aWermke, Nadja$$b5$$udkfz
000120175 7001_ $$aSikorski, Patricia$$b6
000120175 7001_ $$0P:(DE-He78)16e91871b8403eb9e93080b2ff38c0a2$$aSchwarz, Frank$$b7$$udkfz
000120175 7001_ $$0P:(DE-He78)c954da35a243d177fdc4a3924f4f8a5c$$aSchick, Matthias$$b8$$udkfz
000120175 7001_ $$aWuchty, Stefan$$b9
000120175 7001_ $$aAloy, Patrick$$b10
000120175 7001_ $$aUetz, Peter$$b11
000120175 773__ $$0PERI:(DE-600)2071375-7$$a10.1074/mcp.O113.033571$$gVol. 13, no. 5, p. 1318 - 1329$$n5$$p1318 - 1329$$tMolecular & cellular proteomics$$v13$$x1535-9484$$y2014
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