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000120358 1001_ $$0P:(DE-He78)d05b24af674d8ef2c455634434b67770$$aZimmer, Philipp$$b0$$eFirst author$$udkfz
000120358 245__ $$aExercise induced alterations in NK-cell cytotoxicity - methodological issues and future perspectives.
000120358 260__ $$aCopenhagen$$bISEI$$c2017
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000120358 520__ $$aWith their ability to recognize and eliminate virus-infected and neoplastic cells, natural killer cells (NK-cells) represent an important part of the innate immune system. NK-cells have attracted the attention of exercise scientists for more than thirty years ago. To date, it is widely accepted that NK-cell counts in the peripheral blood are strongly influenced by acute exercise. Additionally, many studies reported effects of both, acute and chronic exercise on NK-cell cytotoxicity. However, these findings are contradictory. The inconsistence in findings may be argued with different exercise paradigms (type, duration, intensity). Moreover, strongly varying methods were used to detect NK-cell cytotoxicity. This review gives an overview of studies, investigating the impact of acute and chronic exercise on NK-cell cytotoxicity in young and old healthy adults, as well as on specific populations, such as cancer patients. Furthermore, different methodological approaches to assess NK-cell cytotoxicity are critically discussed to state on inconsistent study results and to give perspectives for further research in this field.
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000120358 7001_ $$aSchenk, Alexander$$b1
000120358 7001_ $$aKieven, Markus$$b2
000120358 7001_ $$aHolthaus, Michelle$$b3
000120358 7001_ $$aLehmann, Jonas$$b4
000120358 7001_ $$aLövenich, Lukas$$b5
000120358 7001_ $$aBloch, Wilhelm$$b6
000120358 773__ $$0PERI:(DE-600)2628162-4$$gVol. 23$$p66-81$$tExercise immunology review$$v23$$x1077-5552$$y2017
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000120358 9141_ $$y2017
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