TY  - JOUR
AU  - Zimmer, Philipp
AU  - Schenk, Alexander
AU  - Kieven, Markus
AU  - Holthaus, Michelle
AU  - Lehmann, Jonas
AU  - Lövenich, Lukas
AU  - Bloch, Wilhelm
TI  - Exercise induced alterations in NK-cell cytotoxicity - methodological issues and future perspectives.
JO  - Exercise immunology review
VL  - 23
SN  - 1077-5552
CY  - Copenhagen
PB  - ISEI
M1  - DKFZ-2017-00792
SP  - 66-81
PY  - 2017
AB  - With their ability to recognize and eliminate virus-infected and neoplastic cells, natural killer cells (NK-cells) represent an important part of the innate immune system. NK-cells have attracted the attention of exercise scientists for more than thirty years ago. To date, it is widely accepted that NK-cell counts in the peripheral blood are strongly influenced by acute exercise. Additionally, many studies reported effects of both, acute and chronic exercise on NK-cell cytotoxicity. However, these findings are contradictory. The inconsistence in findings may be argued with different exercise paradigms (type, duration, intensity). Moreover, strongly varying methods were used to detect NK-cell cytotoxicity. This review gives an overview of studies, investigating the impact of acute and chronic exercise on NK-cell cytotoxicity in young and old healthy adults, as well as on specific populations, such as cancer patients. Furthermore, different methodological approaches to assess NK-cell cytotoxicity are critically discussed to state on inconsistent study results and to give perspectives for further research in this field.
LB  - PUB:(DE-HGF)16
C6  - pmid:28230531
UR  - https://inrepo02.dkfz.de/record/120358
ER  -