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@ARTICLE{Zimmer:120358,
      author       = {P. Zimmer$^*$ and A. Schenk and M. Kieven and M. Holthaus
                      and J. Lehmann and L. Lövenich and W. Bloch},
      title        = {{E}xercise induced alterations in {NK}-cell cytotoxicity -
                      methodological issues and future perspectives.},
      journal      = {Exercise immunology review},
      volume       = {23},
      issn         = {1077-5552},
      address      = {Copenhagen},
      publisher    = {ISEI},
      reportid     = {DKFZ-2017-00792},
      pages        = {66-81},
      year         = {2017},
      abstract     = {With their ability to recognize and eliminate
                      virus-infected and neoplastic cells, natural killer cells
                      (NK-cells) represent an important part of the innate immune
                      system. NK-cells have attracted the attention of exercise
                      scientists for more than thirty years ago. To date, it is
                      widely accepted that NK-cell counts in the peripheral blood
                      are strongly influenced by acute exercise. Additionally,
                      many studies reported effects of both, acute and chronic
                      exercise on NK-cell cytotoxicity. However, these findings
                      are contradictory. The inconsistence in findings may be
                      argued with different exercise paradigms (type, duration,
                      intensity). Moreover, strongly varying methods were used to
                      detect NK-cell cytotoxicity. This review gives an overview
                      of studies, investigating the impact of acute and chronic
                      exercise on NK-cell cytotoxicity in young and old healthy
                      adults, as well as on specific populations, such as cancer
                      patients. Furthermore, different methodological approaches
                      to assess NK-cell cytotoxicity are critically discussed to
                      state on inconsistent study results and to give perspectives
                      for further research in this field.},
      subtyp        = {Review Article},
      cin          = {G210},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28230531},
      url          = {https://inrepo02.dkfz.de/record/120358},
}