Home > Publications database > Exercise induced alterations in NK-cell cytotoxicity - methodological issues and future perspectives. > print

001     120358
005     20240228145443.0
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037 _ _ |a DKFZ-2017-00792
041 _ _ |a eng
082 _ _ |a 610
100 1 _ |a Zimmer, Philipp
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245 _ _ |a Exercise induced alterations in NK-cell cytotoxicity - methodological issues and future perspectives.
260 _ _ |a Copenhagen
|c 2017
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336 7 _ |a article
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336 7 _ |a Journal Article
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520 _ _ |a With their ability to recognize and eliminate virus-infected and neoplastic cells, natural killer cells (NK-cells) represent an important part of the innate immune system. NK-cells have attracted the attention of exercise scientists for more than thirty years ago. To date, it is widely accepted that NK-cell counts in the peripheral blood are strongly influenced by acute exercise. Additionally, many studies reported effects of both, acute and chronic exercise on NK-cell cytotoxicity. However, these findings are contradictory. The inconsistence in findings may be argued with different exercise paradigms (type, duration, intensity). Moreover, strongly varying methods were used to detect NK-cell cytotoxicity. This review gives an overview of studies, investigating the impact of acute and chronic exercise on NK-cell cytotoxicity in young and old healthy adults, as well as on specific populations, such as cancer patients. Furthermore, different methodological approaches to assess NK-cell cytotoxicity are critically discussed to state on inconsistent study results and to give perspectives for further research in this field.
536 _ _ |a 317 - Translational cancer research (POF3-317)
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588 _ _ |a Dataset connected to PubMed,
700 1 _ |a Schenk, Alexander
|b 1
700 1 _ |a Kieven, Markus
|b 2
700 1 _ |a Holthaus, Michelle
|b 3
700 1 _ |a Lehmann, Jonas
|b 4
700 1 _ |a Lövenich, Lukas
|b 5
700 1 _ |a Bloch, Wilhelm
|b 6
773 _ _ |g Vol. 23
|0 PERI:(DE-600)2628162-4
|p 66-81
|t Exercise immunology review
|v 23
|y 2017
|x 1077-5552
909 C O |o oai:inrepo02.dkfz.de:120358
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910 1 _ |a Deutsches Krebsforschungszentrum
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|v Translational cancer research
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|b Gesundheit
914 1 _ |y 2017
915 _ _ |a JCR
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