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@ARTICLE{Hillengass:120390,
      author       = {J. Hillengass$^*$ and M.-A. Weber$^*$ and K. Kilk and K.
                      Listl and B. Wagner-Gund$^*$ and M. Hillengass and T.
                      Hielscher$^*$ and A. Farid and K. Neben and S. Delorme$^*$
                      and O. Landgren and H. Goldschmidt$^*$},
      title        = {{P}rognostic significance of whole-body {MRI} in patients
                      with monoclonal gammopathy of undetermined significance.},
      journal      = {Leukemia},
      volume       = {28},
      number       = {1},
      issn         = {1476-5551},
      address      = {Basingstoke},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2017-00823},
      pages        = {174 - 178},
      year         = {2014},
      abstract     = {Radiological skeletal survey or computed tomography are
                      currently applied to assess bone diseases in patients with
                      monoclonal plasma cell disorders. Whole-body magnetic
                      resonance imaging (whole-body MRI) allows detecting the
                      infiltration of clonal cells in nearly the whole bone marrow
                      compartment even before bone destruction has occurred. Those
                      MRI results (i.e., patterns of bone marrow infiltration)
                      have been demonstrated to be of prognostic significance in
                      patients with symptomatic as well as asymptomatic multiple
                      myeloma. We have therefore analyzed the findings of
                      whole-body MRI in 137 consecutive individuals with
                      monoclonal gammopathy of undetermined significance (MGUS). A
                      focal infiltration pattern was detected in $23.4\%$ of
                      patients. Presence and number of focal lesions as well as
                      value of M-Protein were of independent prognostic
                      significance for progression into a symptomatic disease
                      requiring systemic treatment (P=0.02; P<0.0001 and P=0.0005,
                      respectively). Lower homogeneous signal intensities in
                      T1-weighted images were related to a physiologically higher
                      bone marrow cellularity in younger individuals (P=0.002). We
                      conclude that whole-body MRI identifies patients with focal
                      accumulations of presumably monoclonal cells in bone marrow
                      with prognostic impact concerning the risk of progression
                      into symptomatic disease.},
      cin          = {E013 / E010 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)E013-20160331 / I:(DE-He78)E010-20160331 /
                      I:(DE-He78)C060-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23958921},
      doi          = {10.1038/leu.2013.244},
      url          = {https://inrepo02.dkfz.de/record/120390},
}