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@ARTICLE{Lehners:120407,
      author       = {N. Lehners$^*$ and I. Krämer and M. Saadati$^*$ and A.
                      Benner$^*$ and A. D. Ho and M. Witzens-Harig},
      title        = {{A}nalysis of prognostic factors in patients with newly
                      diagnosed diffuse large {B}-cell lymphoma and skeletal
                      involvement.},
      journal      = {BMC cancer},
      volume       = {17},
      number       = {1},
      issn         = {1471-2407},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2017-00836},
      pages        = {128},
      year         = {2017},
      abstract     = {Skeletal involvement (SI) is observed at low prevalence in
                      patients with diffuse large B-cell lymphoma (DLBCL). Due to
                      the rareness of this particular condition, prospective
                      trials for these patients are scarce.We analyzed clinical
                      characteristics and outcome of 75 patients with DLBCL and SI
                      in order to identify factors with prognostic impact towards
                      progression-free survival (PFS) and overall survival
                      (OS).Limited stage disease (Ann Arbor stage IE-IIE) was
                      present in 34 patients $(45\%),$ 41 patients $(55\%)$ had
                      advanced stage disease (Ann Arbor stage IIIE-IVE). Outcome
                      was generally favorable for patients with DLBCL and SI with
                      3-year OS of $83\%.$ The international prognostic index
                      (IPI) was able to distinguish between different risk groups
                      within this specific entity. Additionally, hypercalcemia
                      showed to be a factor significantly associated with inferior
                      survival. In regard to first-line treatment modalities,
                      consolidative radiotherapy was positively associated with
                      prolonged PFS and OS while intensification of chemotherapy
                      had no significant impact.In our cohort of patients with
                      DLBCL and SI, high-risk IPI as well as presence of
                      hypercalcemia were associated with inferior outcome.
                      Consolidative radiotherapy had a positive impact on
                      survival.},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28193188},
      pmc          = {pmc:PMC5307829},
      doi          = {10.1186/s12885-017-3113-z},
      url          = {https://inrepo02.dkfz.de/record/120407},
}