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@ARTICLE{Dumitru:120519,
      author       = {I. G. Dumitru$^*$ and A. Neitz$^*$ and J. Alfonso$^*$ and
                      H. Monyer$^*$},
      title        = {{D}iazepam {B}inding {I}nhibitor {P}romotes {S}tem {C}ell
                      {E}xpansion {C}ontrolling {E}nvironment-{D}ependent
                      {N}eurogenesis.},
      journal      = {Neuron},
      volume       = {94},
      number       = {1},
      issn         = {0896-6273},
      address      = {[Cambridge, Mass.]},
      publisher    = {Cell Press},
      reportid     = {DKFZ-2017-00948},
      pages        = {125 - 137.e5},
      year         = {2017},
      abstract     = {Plasticity of adult neurogenesis supports adaptation to
                      environmental changes. The identification of molecular
                      mediators that signal these changes to neural progenitors in
                      the niche has remained elusive. Here we report that diazepam
                      binding inhibitor (DBI) is crucial in supporting an adaptive
                      mechanism in response to changes in the environment. We
                      provide evidence that DBI is expressed in stem cells in all
                      neurogenic niches of the postnatal brain. Focusing on the
                      hippocampal subgranular zone (SGZ) and employing multiple
                      genetic manipulations in vivo, we demonstrate that DBI
                      regulates the balance between preserving the stem cell pool
                      and neurogenesis. Specifically, DBI dampens GABA activity in
                      stem cells, thereby sustaining the proproliferative effect
                      of physical exercise and enriched environment. Our data lend
                      credence to the notion that the modulatory effect of DBI
                      constitutes a general mechanism that regulates postnatal
                      neurogenesis.},
      cin          = {A230 / A231},
      ddc          = {610},
      cid          = {I:(DE-He78)A230-20160331 / I:(DE-He78)A231-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28343864},
      doi          = {10.1016/j.neuron.2017.03.003},
      url          = {https://inrepo02.dkfz.de/record/120519},
}