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@ARTICLE{Liu:120560,
      author       = {K.-W. Liu and K. Pajtler$^*$ and B. Worst$^*$ and S. M.
                      Pfister and R. J. Wechsler-Reya},
      title        = {{M}olecular mechanisms and therapeutic targets in pediatric
                      brain tumors.},
      journal      = {Science signaling},
      volume       = {10},
      number       = {470},
      issn         = {1937-9145},
      address      = {Washington, DC [u.a.]},
      publisher    = {Assoc.},
      reportid     = {DKFZ-2017-00989},
      pages        = {eaaf7593},
      year         = {2017},
      abstract     = {Brain tumors are among the leading causes of cancer-related
                      deaths in children. Although surgery, aggressive radiation,
                      and chemotherapy have improved outcomes, many patients still
                      die of their disease. Moreover, those who survive often
                      suffer devastating long-term side effects from the
                      therapies. A greater understanding of the molecular
                      underpinnings of these diseases will drive the development
                      of new therapeutic approaches. Advances in genomics and
                      epigenomics have provided unprecedented insight into the
                      molecular diversity of these diseases and, in several cases,
                      have revealed key genes and signaling pathways that drive
                      tumor growth. These not only serve as potential therapeutic
                      targets but also have facilitated the creation of animal
                      models that faithfully recapitulate the human disease for
                      preclinical studies. In this Review, we discuss recent
                      progress in understanding the molecular basis of the three
                      most common malignant pediatric brain
                      tumors-medulloblastoma, ependymoma, and high-grade
                      glioma-and the implications for development of safer and
                      more effective therapies.},
      subtyp        = {Review Article},
      cin          = {B062 / L101},
      ddc          = {500},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28292958},
      doi          = {10.1126/scisignal.aaf7593},
      url          = {https://inrepo02.dkfz.de/record/120560},
}