TY  - JOUR
AU  - Dell'Albani, Paola
AU  - Di Marco, Barbara
AU  - Grasso, Sonia
AU  - Rocco, Concetta
AU  - Foti, Mario C
TI  - Quercetin derivatives as potent inducers of selective cytotoxicity in glioma cells.
JO  - European journal of pharmaceutical sciences
VL  - 101
SN  - 0928-0987
CY  - New York, NY [u.a.]
PB  - Elsevier
M1  - DKFZ-2017-00998
SP  - 56 - 65
PY  - 2017
AB  - Quercetin (Q) is a flavonoid widely distributed in the plant kingdom and well-known for its ability to exert antioxidant, prooxidant and anticarcinogenic activities in several tumor cells. Furthermore, quercetin plays an important role both in the regulation of key elements in cellular signal transduction pathways related to apoptotic cell death, and in cell cycle progression. Several studies have reported of toxic effects of Q against glioma cell lines. In this study, the effects of Q and of some Q-derivatives (acyl esters and bromo-derivatives) on U373-MG and 9L glioma cell lines survival are analyzed. The 24-hour treatment of glioma cells with several concentrations of Q (25, 50 and 100μM) did not cause any cytotoxic effects, while the administration of Q-derivatives, such as acylated and brominated quercetin, caused a sharp increase in cell death. Among all tested derivatives, 3-O-decanoylquercetin 10 manifested the strongest cytotoxic effect at a concentration as low as 25μM both in U373-MG (ca. 40
LB  - PUB:(DE-HGF)16
C6  - pmid:28153636
DO  - DOI:10.1016/j.ejps.2017.01.036
UR  - https://inrepo02.dkfz.de/record/120569
ER  -