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@ARTICLE{Steindorf:120584,
      author       = {K. Steindorf$^*$ and J. Wiskemann$^*$ and C. M. Ulrich and
                      M. Schmidt$^*$},
      title        = {{E}ffects of exercise on sleep problems in breast cancer
                      patients receiving radiotherapy: a randomized clinical
                      trial.},
      journal      = {Breast cancer research and treatment},
      volume       = {162},
      number       = {3},
      issn         = {1573-7217},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {DKFZ-2017-01013},
      pages        = {489 - 499},
      year         = {2017},
      abstract     = {Sleep problems frequently affect breast cancer patients
                      during and after treatment and reduce their quality of life.
                      Treatment strategies are mostly unknown. Thus, we assessed
                      within a randomized controlled trial whether a 12-week
                      exercise program starting with the radiotherapy influences
                      sleep trajectories.Sleep quality and problems were assessed
                      via self-report in 160 breast cancer patients before,
                      during, and 2, 6, and 12 months after participation in a
                      trial investigating resistance exercise versus a relaxation
                      control group concomitant with radiotherapy. As additional
                      comparison group, 25 age-matched healthy women exercised and
                      followed identical study procedures. Ordinal logistic
                      regression analyses were used.The exercise intervention
                      significantly decreased sleep problems compared to the
                      relaxation control group (scale: 0-100, with between-group
                      mean differences of -10.2 (p = 0.03) from baseline to the
                      end of radiotherapy and -10.9 (p = 0.005) to the end of
                      the intervention), with sleep problems decreasing in the
                      exercise group and increasing in the control group. At
                      12 months, differences were still observed but
                      statistically non-significant (mean difference = -5.9,
                      p = 0.20). Further adjustment for potential confounders
                      did not change the results. Several determinants of sleep
                      problems at baseline were identified, e.g., previous
                      chemotherapy and higher body mass index.Our randomized
                      exercise intervention trial confirmed results from earlier
                      but mostly smaller studies that radiotherapy aggravates
                      sleep problems in breast cancer patients and that exercise
                      can ameliorate these effects. Considering that sleep quality
                      can be a major predictor of quality of life, our findings
                      are of substantial importance to many breast cancer
                      patients.},
      cin          = {G210},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28181128},
      doi          = {10.1007/s10549-017-4141-8},
      url          = {https://inrepo02.dkfz.de/record/120584},
}