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@ARTICLE{Zhan:120590,
      author       = {T. Zhan$^*$ and F. Hahn and T. Hielscher$^*$ and A. Bilge
                      and J. Grüger and J. Weers and J. Betge$^*$ and T. Gaiser
                      and G. Kähler and M. P. Ebert and S. Belle},
      title        = {{M}ultiple behavioral factors are associated with
                      occurrence of large, flat colorectal polyps.},
      journal      = {International journal of colorectal disease},
      volume       = {32},
      number       = {4},
      issn         = {1432-1262},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DKFZ-2017-01019},
      pages        = {575 - 582},
      year         = {2017},
      abstract     = {The prevalence of advanced dysplasia and synchronous
                      lesions is particularly high in patients with large, flat
                      colorectal polyps. However, the impact of lifestyle on the
                      development of such polyps is poorly investigated. Hence,
                      this study aims to identify associations between behavioral
                      factors and the occurrence of large, flat colorectal
                      polyps.Behavioral factors were retrospectively analyzed in
                      patients with large, flat polyps and control patients with
                      at most one diminutive polyp. Information on lifestyle
                      factors, comorbidities, and demographic parameters were
                      determined by a structured, self-administered
                      questionnaire.Questionnaires of 350 patients with large,
                      flat polyps and 489 control patients were included in the
                      analysis. Most large, flat colorectal polyps contained
                      adenoma with low-grade neoplasia and were located in the
                      right colon. Multivariate analysis showed that advanced age
                      (per 1-year increase-OR 1.09, CI 1.07-1.11, p < 0.0001),
                      frequent cigarette smoking (OR 2.04, CI 1.25-3.32,
                      p = 0.0041), daily consumption of red meat (OR 3.61, CI
                      1.00-12.96, p = 0.0492), and frequent bowel movements (OR
                      1.62, CI 1.13-2.33, p = 0.0093) were independent risk
                      factors for occurrence of large, flat colorectal polyps. In
                      contrast, frequent intake of cereals (OR 0.62, CI 0.44-0.88,
                      p = 0.0074) was associated with a reduced risk.Multiple
                      behavioral factors modulate the risk for developing large,
                      flat colorectal polyps. This knowledge can be used to
                      improve prevention of colorectal cancer.},
      cin          = {B110 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)B110-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27896421},
      doi          = {10.1007/s00384-016-2717-0},
      url          = {https://inrepo02.dkfz.de/record/120590},
}