%0 Journal Article
%A Freitag, Martin
%A Radtke, Jan Philipp
%A Afshar-Oromieh, Ali
%A Roethke, Matthias C
%A Hadaschik, Boris A
%A Gleave, Martin
%A Bonekamp, David
%A Kopka, Klaus
%A Eder, Matthias
%A Heusser, Thorsten
%A Kachelriess, Marc
%A Wieczorek, Kathrin
%A Sachpekidis, Christos
%A Flechsig, Paul
%A Giesel, Frederik
%A Hohenfellner, Markus
%A Haberkorn, Uwe
%A Schlemmer, Heinz-Peter
%A Dimitrakopoulou-Strauss, A.
%T Local recurrence of prostate cancer after radical prostatectomy is at risk to be missed in (68)Ga-PSMA-11-PET of PET/CT and PET/MRI: comparison with mpMRI integrated in simultaneous PET/MRI.
%J European journal of nuclear medicine and molecular imaging
%V 44
%N 5
%@ 1619-7089
%C Heidelberg [u.a.]
%I Springer-Verl.
%M DKFZ-2017-01024
%P 776 - 787
%D 2017
%X The positron emission tomography (PET) tracer (68)Ga-PSMA-11, targeting the prostate-specific membrane antigen (PSMA), is rapidly excreted into the urinary tract. This leads to significant radioactivity in the bladder, which may limit the PET-detection of local recurrence (LR) of prostate cancer (PC) after radical prostatectomy (RP), developing in close proximity to the bladder. Here, we analyze if there is additional value of multi-parametric magnetic resonance imaging (mpMRI) compared to the (68)Ga-PSMA-11-PET-component of PET/CT or PET/MRI to detect LR.One hundred and nineteen patients with biochemical recurrence after prior RP underwent both hybrid (68)Ga-PSMA-11-PET/CTlow-dose (1 h p.i.) and -PET/MRI (2-3 h p.i.) including a mpMRI protocol of the prostatic bed. The comparison of both methods was restricted to the abdomen with focus on LR (McNemar). Bladder-LR distance and recurrence size were measured in axial T2w-TSE. A logistic regression was performed to determine the influence of these variables on detectability in (68)Ga-PSMA-11-PET. Standardized-uptake-value (SUVmean) quantification of LR was performed.There were 93/119 patients that had at least one pathologic finding. In addition, 18/119 Patients (15.1
%K (68Ga)Glu-urea-Lys(Ahx)-HBED-CC (NLM Chemicals)
%K Organometallic Compounds (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:27988802
%R 10.1007/s00259-016-3594-z
%U https://inrepo02.dkfz.de/record/120596