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000120596 0247_ $$2ISSN$$a1432-105X
000120596 0247_ $$2ISSN$$a1619-7070
000120596 0247_ $$2ISSN$$a1619-7089
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000120596 1001_ $$0P:(DE-He78)c420f6efccb409e1a287be027501a74c$$aFreitag, Martin$$b0$$eFirst author
000120596 245__ $$aLocal recurrence of prostate cancer after radical prostatectomy is at risk to be missed in (68)Ga-PSMA-11-PET of PET/CT and PET/MRI: comparison with mpMRI integrated in simultaneous PET/MRI.
000120596 260__ $$aHeidelberg [u.a.]$$bSpringer-Verl.$$c2017
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000120596 520__ $$aThe positron emission tomography (PET) tracer (68)Ga-PSMA-11, targeting the prostate-specific membrane antigen (PSMA), is rapidly excreted into the urinary tract. This leads to significant radioactivity in the bladder, which may limit the PET-detection of local recurrence (LR) of prostate cancer (PC) after radical prostatectomy (RP), developing in close proximity to the bladder. Here, we analyze if there is additional value of multi-parametric magnetic resonance imaging (mpMRI) compared to the (68)Ga-PSMA-11-PET-component of PET/CT or PET/MRI to detect LR.One hundred and nineteen patients with biochemical recurrence after prior RP underwent both hybrid (68)Ga-PSMA-11-PET/CTlow-dose (1 h p.i.) and -PET/MRI (2-3 h p.i.) including a mpMRI protocol of the prostatic bed. The comparison of both methods was restricted to the abdomen with focus on LR (McNemar). Bladder-LR distance and recurrence size were measured in axial T2w-TSE. A logistic regression was performed to determine the influence of these variables on detectability in (68)Ga-PSMA-11-PET. Standardized-uptake-value (SUVmean) quantification of LR was performed.There were 93/119 patients that had at least one pathologic finding. In addition, 18/119 Patients (15.1%) were diagnosed with a LR in mpMRI of PET/MRI but only nine were PET-positive in PET/CT and PET/MRI. This mismatch was statistically significant (p = 0.004). Detection of LR using the PET-component was significantly influenced by proximity to the bladder (p = 0.028). The PET-pattern of LR-uptake was classified into three types (1): separated from bladder; (2): fuses with bladder, and (3): obliterated by bladder). The size of LRs did not affect PET-detectability (p = 0.84), mean size was 1.7 ± 0.69 cm long axis, 1.2 ± 0.46 cm short-axis. SUVmean in nine men was 8.7 ± 3.7 (PET/CT) and 7.0 ± 4.2 (PET/MRI) but could not be quantified in the remaining nine cases (obliterated by bladder).The present study demonstrates additional value of hybrid (68)Ga-PSMA-11-PET/MRI by gaining complementary diagnostic information compared to (the 68)Ga-PSMA-11-PET/CTlow-dose for patients with LR of PC.
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000120596 650_7 $$2NLM Chemicals$$a(68Ga)Glu-urea-Lys(Ahx)-HBED-CC
000120596 650_7 $$2NLM Chemicals$$aOrganometallic Compounds
000120596 7001_ $$0P:(DE-He78)79897f8897ff77676549d9895258a0f2$$aRadtke, Jan Philipp$$b1
000120596 7001_ $$0P:(DE-He78)440aad6e9a60396ff0bcd7c2862db18c$$aAfshar-Oromieh, Ali$$b2
000120596 7001_ $$0P:(DE-HGF)0$$aRoethke, Matthias C$$b3
000120596 7001_ $$aHadaschik, Boris A$$b4
000120596 7001_ $$aGleave, Martin$$b5
000120596 7001_ $$0P:(DE-He78)ea098e4d78abeb63afaf8c25ec6d6d93$$aBonekamp, David$$b6
000120596 7001_ $$0P:(DE-He78)9793347ba83f527b81a22ab75af9378a$$aKopka, Klaus$$b7
000120596 7001_ $$0P:(DE-He78)331382460d902d1341dc73db8b990f97$$aEder, Matthias$$b8
000120596 7001_ $$0P:(DE-He78)a00a109668c5fdbeea213d6981588250$$aHeusser, Thorsten$$b9$$udkfz
000120596 7001_ $$0P:(DE-He78)f288a8f92f092ddb41d52b1aeb915323$$aKachelriess, Marc$$b10
000120596 7001_ $$aWieczorek, Kathrin$$b11
000120596 7001_ $$0P:(DE-He78)69d2d5247c019c2a2075502dc11bf0b2$$aSachpekidis, Christos$$b12
000120596 7001_ $$aFlechsig, Paul$$b13
000120596 7001_ $$0P:(DE-He78)5ca7e97b2769bb97f8c73431c6566b94$$aGiesel, Frederik$$b14
000120596 7001_ $$aHohenfellner, Markus$$b15
000120596 7001_ $$0P:(DE-He78)13a0afba029f5f64dc18b25ef7499558$$aHaberkorn, Uwe$$b16
000120596 7001_ $$0P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec$$aSchlemmer, Heinz-Peter$$b17
000120596 7001_ $$0P:(DE-He78)b2df3652dfa3e19d5e96dfc53f44a992$$aDimitrakopoulou-Strauss, A.$$b18$$eLast author
000120596 773__ $$0PERI:(DE-600)2098375-X$$a10.1007/s00259-016-3594-z$$gVol. 44, no. 5, p. 776 - 787$$n5$$p776 - 787$$tEuropean journal of nuclear medicine and molecular imaging$$v44$$x1619-7089$$y2017
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