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@ARTICLE{Niklas:120610,
      author       = {M. Niklas$^*$ and M. Henrich$^*$ and O. Jäkel$^*$ and J.
                      Engelhardt$^*$ and A. Abdollahi$^*$ and S. Greilich$^*$},
      title        = {{STED} microscopy visualizes energy deposition of single
                      ions in a solid-state detector beyond diffraction limit.},
      journal      = {Physics in medicine and biology},
      volume       = {62},
      number       = {9},
      issn         = {1361-6560},
      address      = {Bristol},
      publisher    = {IOP Publ.},
      reportid     = {DKFZ-2017-01038},
      pages        = {N180 - N190},
      year         = {2017},
      abstract     = {Fluorescent nuclear track detectors (FNTDs) allow for
                      visualization of single-particle traversal in clinical ion
                      beams. The point spread function of the confocal readout has
                      so far hindered a more detailed characterization of the
                      track spots-the ion's characteristic signature left in the
                      FNTD. Here we report on the readout of the FNTD by optical
                      nanoscopy, namely stimulated emission depletion microscopy.
                      It was firstly possible to visualize the track spots of
                      carbon ions and protons beyond the diffraction limit of
                      conventional light microscopy with a resolving power of
                      approximately 80 nm (confocal: 320 nm). A clear
                      discrimination of the spatial width, defined by the full
                      width half maximum of track spots from particles (proton and
                      carbon ions), with a linear energy transfer (LET) ranging
                      from approximately 2-1016 keV µm(-1) was possible.
                      Results suggest that the width depends on LET but not on
                      particle charge within the uncertainties. A discrimination
                      of particle type by width thus does not seem possible (as
                      well as with confocal microscopy). The increased resolution,
                      however, could allow for refined determination of the
                      cross-sectional area facing substantial energy deposition.
                      This work could pave the way towards development of optical
                      nanoscopy-based analysis of radiation-induced cellular
                      response using cell-fluorescent ion track hybrid detectors.},
      cin          = {E210 / L101 / E040 / E190 ; E190},
      ddc          = {570},
      cid          = {I:(DE-He78)E210-20160331 / I:(DE-He78)L101-20160331 /
                      I:(DE-He78)E040-20160331 / I:(DE-He78)E190-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28379846},
      doi          = {10.1088/1361-6560/aa5edc},
      url          = {https://inrepo02.dkfz.de/record/120610},
}