%0 Journal Article
%A Bickelhaupt, Sebastian
%A Steudle, Franziska
%A Paech, Daniel
%A Mlynarska, Anna
%A Kuder, Tristan Anselm
%A Lederer, Wolfgang
%A Daniel, Heidi
%A Freitag, Martin
%A Delorme, Stefan
%A Schlemmer, Heinz-Peter
%A Laun, Frederik Bernd
%T On a fractional order calculus model in diffusion weighted breast imaging to differentiate between malignant and benign breast lesions detected on X-ray screening mammography.
%J PLoS one
%V 12
%N 4
%@ 1932-6203
%C Lawrence, Kan.
%I PLoS
%M DKFZ-2017-01047
%P e0176077 -
%D 2017
%X To evaluate a fractional order calculus (FROC) model in diffusion weighted imaging to differentiate between malignant and benign breast lesions in breast cancer screening work-up using recently introduced parameters (βFROC, DFROC and μFROC).This retrospective analysis within a prospective IRB-approved study included 51 participants (mean 58.4 years) after written informed consent. All patients had suspicious screening mammograms and indication for biopsy. Prior to biopsy, full diagnostic contrast-enhanced MRI examination was acquired including diffusion-weighted-imaging (DWI, b = 0,100,750,1500 s/mm2). Conventional apparent diffusion coefficient Dapp and FROC parameters (βFROC, DFROC and μFROC) as suggested further indicators of diffusivity components were measured in benign and malignant lesions. Receiver operating characteristics (ROC) were calculated to evaluate the diagnostic performance of the parameters.29/51 patients histopathologically revealed malignant lesions. The analysis revealed an AUC for Dapp of 0.89 (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28453516
%2 pmc:PMC5409173
%R 10.1371/journal.pone.0176077
%U https://inrepo02.dkfz.de/record/120619