TY  - JOUR
AU  - Bickelhaupt, Sebastian
AU  - Steudle, Franziska
AU  - Paech, Daniel
AU  - Mlynarska, Anna
AU  - Kuder, Tristan Anselm
AU  - Lederer, Wolfgang
AU  - Daniel, Heidi
AU  - Freitag, Martin
AU  - Delorme, Stefan
AU  - Schlemmer, Heinz-Peter
AU  - Laun, Frederik Bernd
TI  - On a fractional order calculus model in diffusion weighted breast imaging to differentiate between malignant and benign breast lesions detected on X-ray screening mammography.
JO  - PLoS one
VL  - 12
IS  - 4
SN  - 1932-6203
CY  - Lawrence, Kan.
PB  - PLoS
M1  - DKFZ-2017-01047
SP  - e0176077 -
PY  - 2017
AB  - To evaluate a fractional order calculus (FROC) model in diffusion weighted imaging to differentiate between malignant and benign breast lesions in breast cancer screening work-up using recently introduced parameters (βFROC, DFROC and μFROC).This retrospective analysis within a prospective IRB-approved study included 51 participants (mean 58.4 years) after written informed consent. All patients had suspicious screening mammograms and indication for biopsy. Prior to biopsy, full diagnostic contrast-enhanced MRI examination was acquired including diffusion-weighted-imaging (DWI, b = 0,100,750,1500 s/mm2). Conventional apparent diffusion coefficient Dapp and FROC parameters (βFROC, DFROC and μFROC) as suggested further indicators of diffusivity components were measured in benign and malignant lesions. Receiver operating characteristics (ROC) were calculated to evaluate the diagnostic performance of the parameters.29/51 patients histopathologically revealed malignant lesions. The analysis revealed an AUC for Dapp of 0.89 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:28453516
C2  - pmc:PMC5409173
DO  - DOI:10.1371/journal.pone.0176077
UR  - https://inrepo02.dkfz.de/record/120619
ER  -