%0 Journal Article
%A Holzinger, Dana
%A Wichmann, Gunnar
%A Baboci, Lorena
%A Michel, Angelika
%A Höfler, Daniela
%A Wiesenfarth, Manuel
%A Schroeder, Lea
%A Boscolo-Rizzo, Paolo
%A Herold-Mende, Christel
%A Dyckhoff, Gerhard
%A Boehm, Andreas
%A Del Mistro, Annarosa
%A Bosch, Franz X
%A Dietz, Andreas
%A Pawlita, Michael
%A Waterboer, Tim
%T Sensitivity and specificity of antibodies against HPV16 E6 and other early proteins for the detection of HPV16-driven oropharyngeal squamous cell carcinoma.
%J International journal of cancer
%V 140
%N 12
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2017-01076
%P 2748 - 2757
%D 2017
%X To determine the sensitivity and specificity of HPV16 serology as diagnostic marker for HPV16-driven oropharyngeal squamous cell carcinoma (OPSCC), 214 HNSCC patients from Germany and Italy with fresh-frozen tumor tissues and sera collected before treatment were included in this study. Hundred and twenty cancer cases were from the oropharynx and 94 were from head and neck cancer regions outside the oropharynx (45 oral cavity, 12 hypopharynx and 35 larynx). Serum antibodies to early (E1, E2, E6 and E7) and late (L1) HPV16 proteins were analyzed by multiplex serology and were compared to tumor HPV RNA status as the gold standard. A tumor was defined as HPV-driven in the presence of HPV16 DNA and HPV16 transformation-specific RNA transcript patterns (E6*I, E1(∧) E4 and E1C). Of 120 OPSCC, 66 (55
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28316084
%R 10.1002/ijc.30697
%U https://inrepo02.dkfz.de/record/120649