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@ARTICLE{Bertleff:120671,
      author       = {M. Bertleff and S. Domsch and F. Laun$^*$ and T. A.
                      Kuder$^*$ and L. R. Schad},
      title        = {1{D} and 2{D} diffusion pore imaging on a preclinical {MR}
                      system using adaptive rephasing: {F}easibility and pulse
                      sequence comparison.},
      journal      = {Journal of magnetic resonance},
      volume       = {278},
      issn         = {1090-7807},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2017-01097},
      pages        = {39 - 50},
      year         = {2017},
      abstract     = {Diffusion pore imaging (DPI) has recently been proposed as
                      a means to acquire images of the average pore shape in an
                      image voxel or region of interest. The highly asymmetric
                      gradient scheme of its sequence makes it substantially
                      demanding in terms of the hardware of the NMR system. The
                      aim of this work is to show the feasibility of DPI on a
                      preclinical 9.4T animal scanner. Using water-filled
                      capillaries with an inner radius of 10μm, four different
                      variants of the DPI sequence were compared in 1D and 2D
                      measurements. The pulse sequences applied cover the basic
                      implementation using one long and one temporally narrow
                      gradient pulse, a CPMG-like variant with multiple refocusing
                      RF pulses as well as two variants splitting up the long
                      gradient and distributing it on either side of the
                      refocusing pulse. Substantial differences between the
                      methods were found in terms of signal-to-noise ratio,
                      contrast, blurring, deviations from the expected results and
                      sensitivity to gradient imperfections. Each of the tested
                      sequences was found to produce characteristic gradient
                      mismatches dependent on the absolute value, direction and
                      sign of the applied q-value. Read gradients were applied to
                      compensate these mismatches translating them into time
                      shifts, which enabled 1D DPI yielding capillary radius
                      estimations within the tolerances specified by the
                      manufacturer. For a successful DPI application in 2D, a
                      novel gradient amplitude adaption scheme was implemented to
                      correct for the occurring time shifts. Using this adaption,
                      higher conformity to the expected pore shape, reduced
                      blurring and enhanced contrast were achieved. Images of the
                      phantom's pore shape could be acquired with a nominal
                      resolution of 2.2μm.},
      cin          = {E020},
      ddc          = {550},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28351813},
      doi          = {10.1016/j.jmr.2017.03.008},
      url          = {https://inrepo02.dkfz.de/record/120671},
}