TY  - JOUR
AU  - Fusenig, Norbert
AU  - Capes-Davis, Amanda
AU  - Bianchini, Franca
AU  - Sundell, Sherryl
AU  - Lichter, Peter
TI  - The need for a worldwide consensus for cell line authentication: Experience implementing a mandatory requirement at the International Journal of Cancer.
JO  - PLoS biology
VL  - 15
IS  - 4
SN  - 1545-7885
CY  - Lawrence, KS
PB  - PLoS
M1  - DKFZ-2017-01101
SP  - e2001438 -
PY  - 2017
AB  - Cell lines are used in life science research worldwide as biological surrogates. All cell lines are subject to major limitations when used as research tools, including (i) cross-contamination with other cells cultured in the same laboratory environment and (ii) evolution in vitro that renders a given cell line inappropriate as a surrogate for a specific biological hypothesis. There is ample evidence that cross-contamination or phenotypic drift of cells in culture can generate irreproducible or misleading data. A small number of scientific journals-the International Journal of Cancer being at the forefront-and funding agencies have recently moved forward to ask for obligatory cell line authentication data. The history of implementing such rules by the International Journal of Cancer exemplifies the difficulties encountered when installing mandatory quality measures in life sciences.
LB  - PUB:(DE-HGF)16
C6  - pmid:28414712
C2  - pmc:PMC5393552
DO  - DOI:10.1371/journal.pbio.2001438
UR  - https://inrepo02.dkfz.de/record/120675
ER  -