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@ARTICLE{Fusenig:120675,
author = {N. Fusenig$^*$ and A. Capes-Davis and F. Bianchini$^*$ and
S. Sundell and P. Lichter$^*$},
title = {{T}he need for a worldwide consensus for cell line
authentication: {E}xperience implementing a mandatory
requirement at the {I}nternational {J}ournal of {C}ancer.},
journal = {PLoS biology},
volume = {15},
number = {4},
issn = {1545-7885},
address = {Lawrence, KS},
publisher = {PLoS},
reportid = {DKFZ-2017-01101},
pages = {e2001438 -},
year = {2017},
abstract = {Cell lines are used in life science research worldwide as
biological surrogates. All cell lines are subject to major
limitations when used as research tools, including (i)
cross-contamination with other cells cultured in the same
laboratory environment and (ii) evolution in vitro that
renders a given cell line inappropriate as a surrogate for a
specific biological hypothesis. There is ample evidence that
cross-contamination or phenotypic drift of cells in culture
can generate irreproducible or misleading data. A small
number of scientific journals-the International Journal of
Cancer being at the forefront-and funding agencies have
recently moved forward to ask for obligatory cell line
authentication data. The history of implementing such rules
by the International Journal of Cancer exemplifies the
difficulties encountered when installing mandatory quality
measures in life sciences.},
cin = {M120 / V962 / B060 / L101},
ddc = {500},
cid = {I:(DE-He78)M120-20160331 / I:(DE-He78)V962-20160331 /
I:(DE-He78)B060-20160331 / I:(DE-He78)L101-20160331},
pnm = {312 - Functional and structural genomics (POF3-312)},
pid = {G:(DE-HGF)POF3-312},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:28414712},
pmc = {pmc:PMC5393552},
doi = {10.1371/journal.pbio.2001438},
url = {https://inrepo02.dkfz.de/record/120675},
}