TY  - JOUR
AU  - Schönsteiner, Stefan S
AU  - Bauder Mißbach, Heidi
AU  - Benner, Axel
AU  - Mack, Silja
AU  - Hamel, Thomas
AU  - Orth, Michael
AU  - Landwehrmeyer, Bernhard
AU  - Süßmuth, Sigurd D
AU  - Geitner, Carolin
AU  - Mayer-Steinacker, Regine
AU  - Riester, Anneliese
AU  - Prokein, Andrea
AU  - Erhardt, Elfriede
AU  - Kunecki, Jelena
AU  - Eisenschink, Anna M
AU  - Rawer, Rainer
AU  - Döhner, Hartmut
AU  - Kirchner, Elisabeth
AU  - Schlenk, Richard
TI  - A randomized exploratory phase 2 study in patients with chemotherapy-related peripheral neuropathy evaluating whole-body vibration training as adjunct to an integrated program including massage, passive mobilization and physical exercises.
JO  - Experimental hematology & oncology
VL  - 6
IS  - 1
SN  - 2162-3619
CY  - London
PB  - Biomed Central
M1  - DKFZ-2017-01127
SP  - 5
PY  - 2017
AB  - Chemotherapy-induced polyneuropathy (CIPN) is a common toxicity after chemotherapy, immunomodulatory drugs or proteasome inhibitors, which is difficult to treat and may also have impact on quality of life. The objective of the study was to evaluate whole-body vibration (WBV) on the background of an integrated program (IP) including massage, passive mobilization and physical exercises on CIPN.In an exploratory phase-2 study patients with CIPN (NCI CTC grade 2/3) were randomized for WBV plus IP (experimental) to IP alone (standard). 15 training sessions within 15 weeks were intended. As primary endpoint we used chair-rising test (CRT) to assess physical fitness and coordination. In addition, locomotor and neurological tests and self-assessment tools were performed.A total 131 patients with CIPN were randomized (standard, n = 65; experimental, n = 66). The median age was 60 (range 24-71) years; 44 patients had haematological neoplasms and 87 solid tumors. At baseline, all patients presented with an abnormal CRT. Fifteen (standard) and 22 (experimental) patients left the program due to progression/relapse or concomitant disease. There was no significant difference in the proportion of patients with normal CRT (<10 s) at follow up between experimental (68
LB  - PUB:(DE-HGF)16
C6  - pmid:28194306
C2  - pmc:PMC5297221
DO  - DOI:10.1186/s40164-017-0065-6
UR  - https://inrepo02.dkfz.de/record/124231
ER  -