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@ARTICLE{Schnsteiner:124231,
      author       = {S. S. Schönsteiner and H. Bauder Mißbach and A.
                      Benner$^*$ and S. Mack and T. Hamel and M. Orth and B.
                      Landwehrmeyer and S. D. Süßmuth and C. Geitner and R.
                      Mayer-Steinacker and A. Riester and A. Prokein and E.
                      Erhardt and J. Kunecki and A. M. Eisenschink and R. Rawer
                      and H. Döhner and E. Kirchner and R. Schlenk$^*$},
      title        = {{A} randomized exploratory phase 2 study in patients with
                      chemotherapy-related peripheral neuropathy evaluating
                      whole-body vibration training as adjunct to an integrated
                      program including massage, passive mobilization and physical
                      exercises.},
      journal      = {Experimental hematology $\&$ oncology},
      volume       = {6},
      number       = {1},
      issn         = {2162-3619},
      address      = {London},
      publisher    = {Biomed Central},
      reportid     = {DKFZ-2017-01127},
      pages        = {5},
      year         = {2017},
      abstract     = {Chemotherapy-induced polyneuropathy (CIPN) is a common
                      toxicity after chemotherapy, immunomodulatory drugs or
                      proteasome inhibitors, which is difficult to treat and may
                      also have impact on quality of life. The objective of the
                      study was to evaluate whole-body vibration (WBV) on the
                      background of an integrated program (IP) including massage,
                      passive mobilization and physical exercises on CIPN.In an
                      exploratory phase-2 study patients with CIPN (NCI CTC grade
                      2/3) were randomized for WBV plus IP (experimental) to IP
                      alone (standard). 15 training sessions within 15 weeks were
                      intended. As primary endpoint we used chair-rising test
                      (CRT) to assess physical fitness and coordination. In
                      addition, locomotor and neurological tests and
                      self-assessment tools were performed.A total 131 patients
                      with CIPN were randomized (standard, n = 65; experimental,
                      n = 66). The median age was 60 (range 24-71) years; 44
                      patients had haematological neoplasms and 87 solid tumors.
                      At baseline, all patients presented with an abnormal CRT.
                      Fifteen (standard) and 22 (experimental) patients left the
                      program due to progression/relapse or concomitant disease.
                      There was no significant difference in the proportion of
                      patients with normal CRT (<10 s) at follow up between
                      experimental $(68\%)$ and standard $(56\%)$ (p = 0.20).
                      All patients experienced less symptoms and pain
                      (p < 0.001) and had improved CRT (p < 0.001) over time.
                      WBV was significantly associated with a higher reduction of
                      time needed for CRT (p = 0.02) and significantly improved
                      warm-detection-threshold comparing baseline to follow-up
                      assessment (p = 0.02).Whole-body vibration on the
                      background of an IP may improve physical fitness and
                      coordination in patients suffering from CIPN. Trial
                      registration Retrospectively registered at
                      http://www.iscrtn.com (ISRCTN 51361937) and
                      http://www.clinicaltrials.gov (NCT02846844).},
      cin          = {G040 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)G040-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28194306},
      pmc          = {pmc:PMC5297221},
      doi          = {10.1186/s40164-017-0065-6},
      url          = {https://inrepo02.dkfz.de/record/124231},
}