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@ARTICLE{Goeppert:124240,
      author       = {B. Goeppert and S. Roessler and N. Becker$^*$ and M.
                      Zucknick and M. N. Vogel and A. Warth and A. Pathil-Warth
                      and A. Mehrabi and P. Schirmacher and J. Mollenhauer and M.
                      Renner},
      title        = {{DMBT}1 expression in biliary carcinogenesis with
                      correlation of clinicopathological data.},
      journal      = {Histopathology},
      volume       = {70},
      number       = {7},
      issn         = {0309-0167},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2017-01136},
      pages        = {1064 - 1071},
      year         = {2017},
      abstract     = {Deleted in malignant brain tumours 1 (DMBT1) exerts
                      functions in the regulation of epithelial differentiation
                      and inflammation and has been proposed as a tumour
                      suppressor. Because chronic inflammation is a hallmark of
                      cholangiocarcinogenesis, the aim of this study was to
                      investigate the expression of DMBT1 in biliary tract cancer
                      (BTC) and to correlate this expression with
                      clinicopathological data.The expression of DMBT1 protein was
                      examined immunohistochemically in 157 BTC patients [41
                      intrahepatic (ICC), 60 extrahepatic cholangiocarcinomas
                      (ECC) and 56 adenocarcinomas of the gallbladder (GBAC)].
                      Additionally, 56 samples of high-grade biliary
                      intraepithelial neoplasia (BilIN 3) and 92 corresponding
                      samples of histological non-neoplastic biliary tract tissues
                      were included. DMBT1 expression was increased significantly
                      in BilIN 3 compared to normal tissue (P < 0.0001) and BTC (P
                      < 0.0001). BTC showed no significant difference in DMBT1
                      expression compared to non-neoplastic biliary tissue (P =
                      0.315). Absent DMBT1 expression in non-neoplastic biliary
                      tissue of BTC patients was associated with poorer survival
                      (P = 0.027). DMBT1 expression was correlated significantly
                      with patients' age (P < 0.001).DMBT1 is expressed
                      differently in cholangiocarcinogenesis and poorer patients'
                      survival rates are associated with absent DMBT1 expression
                      in non-neoplastic biliary tissue, suggesting a
                      tumour-suppressive role of DMBT1 in early
                      cholangiocarcinogenesis.},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28130841},
      doi          = {10.1111/his.13175},
      url          = {https://inrepo02.dkfz.de/record/124240},
}