%0 Journal Article
%A Mynarek, Martin
%A Pizer, Barry
%A Dufour, Christelle
%A van Vuurden, Dannis
%A Garami, Miklos
%A Massimino, Maura
%A Fangusaro, Jason
%A Davidson, Tom
%A Gil-da-Costa, Maria Joao
%A Sterba, Jaroslav
%A Benesch, Martin
%A Gerber, Nicolas
%A Juhnke, B Ole
%A Kwiecien, Robert
%A Pietsch, Torsten
%A Kool, Marcel
%A Clifford, Steve
%A Ellison, David W
%A Giangaspero, Felice
%A Wesseling, Pieter
%A Gilles, Floyd
%A Gottardo, Nicholas
%A Finlay, Jonathan L
%A Rutkowski, Stefan
%A von Hoff, Katja
%T Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: analysis of pooled European Society for Paediatric Oncology (SIOP-E) and US Head Start data.
%J Neuro-Oncology
%V 19
%N 4
%@ 1523-5866
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2017-01141
%P 576-585
%D 2017
%X Pineoblastoma is a rare pineal region brain tumor. Treatment strategies have reflected those for other malignant embryonal brain tumors.Original prospective treatment and outcome data from international trial groups were pooled. Cox regression models were developed considering treatment elements as time-dependent covariates.Data on 135 patients with pineoblastoma aged 0.01-20.7 (median 4.9) years were analyzed. Median observation time was 7.3 years. Favorable prognostic factors were age ≥4 years (hazard ratio [HR] for progression-free survival [PFS] 0.270, P < .001) and administration of radiotherapy (HR for PFS 0.282, P < .001). Metastatic disease (HR for PFS 2.015, P = .006), but not postoperative residual tumor, was associated with unfavorable prognosis. In 57 patients <4 years old, 5-year PFS/overall survival (OS) were 11 ± 4
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28011926
%2 pmc:PMC5464312
%R 10.1093/neuonc/now234
%U https://inrepo02.dkfz.de/record/124245