TY  - JOUR
AU  - Mynarek, Martin
AU  - Pizer, Barry
AU  - Dufour, Christelle
AU  - van Vuurden, Dannis
AU  - Garami, Miklos
AU  - Massimino, Maura
AU  - Fangusaro, Jason
AU  - Davidson, Tom
AU  - Gil-da-Costa, Maria Joao
AU  - Sterba, Jaroslav
AU  - Benesch, Martin
AU  - Gerber, Nicolas
AU  - Juhnke, B Ole
AU  - Kwiecien, Robert
AU  - Pietsch, Torsten
AU  - Kool, Marcel
AU  - Clifford, Steve
AU  - Ellison, David W
AU  - Giangaspero, Felice
AU  - Wesseling, Pieter
AU  - Gilles, Floyd
AU  - Gottardo, Nicholas
AU  - Finlay, Jonathan L
AU  - Rutkowski, Stefan
AU  - von Hoff, Katja
TI  - Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: analysis of pooled European Society for Paediatric Oncology (SIOP-E) and US Head Start data.
JO  - Neuro-Oncology
VL  - 19
IS  - 4
SN  - 1523-5866
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2017-01141
SP  - 576-585
PY  - 2017
AB  - Pineoblastoma is a rare pineal region brain tumor. Treatment strategies have reflected those for other malignant embryonal brain tumors.Original prospective treatment and outcome data from international trial groups were pooled. Cox regression models were developed considering treatment elements as time-dependent covariates.Data on 135 patients with pineoblastoma aged 0.01-20.7 (median 4.9) years were analyzed. Median observation time was 7.3 years. Favorable prognostic factors were age ≥4 years (hazard ratio [HR] for progression-free survival [PFS] 0.270, P < .001) and administration of radiotherapy (HR for PFS 0.282, P < .001). Metastatic disease (HR for PFS 2.015, P = .006), but not postoperative residual tumor, was associated with unfavorable prognosis. In 57 patients <4 years old, 5-year PFS/overall survival (OS) were 11 ± 4
LB  - PUB:(DE-HGF)16
C6  - pmid:28011926
C2  - pmc:PMC5464312
DO  - DOI:10.1093/neuonc/now234
UR  - https://inrepo02.dkfz.de/record/124245
ER  -