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@ARTICLE{Schmidt:124251,
      author       = {A. Schmidt$^*$ and C. C. Rieger$^*$ and R. K. Venigalla and
                      S. Éliás and R. Max and H.-M. Lorenz and H.-J. Gröne$^*$
                      and P. Krammer$^*$ and A. Kuhn$^*$},
      title        = {{A}nalysis of {FOXP}3(+) regulatory {T} cell subpopulations
                      in peripheral blood and tissue of patients with systemic
                      lupus erythematosus.},
      journal      = {Immunologic research},
      volume       = {65},
      number       = {2},
      issn         = {1559-0755},
      address      = {Totowa, NJ},
      publisher    = {Humana Press},
      reportid     = {DKFZ-2017-01147},
      pages        = {551 - 563},
      year         = {2017},
      abstract     = {Regulatory T cells (Tregs) are critical mediators of immune
                      tolerance, yet their involvement in the autoimmune disease
                      systemic lupus erythematosus (SLE) is incompletely
                      understood. We analyzed CD4(+) T cell subpopulations with
                      Treg-related phenotypes and their association with disease
                      activity in peripheral blood (PB) and tissues of patients
                      with SLE. In detail, we quantified subpopulations regarding
                      CD25, FOXP3, CD62L, CCR6, CD27, CD45RA, and CD45RO
                      expression in PB from 31 patients with SLE divided into two
                      disease activity groups and 32 healthy controls using flow
                      cytometry. CD4(+) and FOXP3(+) T cells in skin and kidney
                      biopsies of patients with SLE were quantified by
                      immunohistochemistry. CD4(+)CD25(+/++)FOXP3(+) and
                      CD4(+)CD25(+)CD45RA(-)/CD45RO(+) T cell frequencies were
                      significantly higher in PB from patients with active
                      compared to inactive SLE. The fraction of
                      CD4(+)CD25(++)FOXP3(+) Tregs and
                      CD4(+)CD25(+)CD45RA(+)/CD45RO(-) naïve Tregs was not
                      significantly different between these groups. CD4(+)CD25(++)
                      Tregs from active SLE patients comprised significantly less
                      CD27(+) cells and more CCR6(+) cells compared to patients
                      with inactive SLE. The percentage of CD4(+)FOXP3(+) T cells
                      among inflammatory infiltrates in skin and kidney biopsies
                      of SLE patients was not different from other inflammatory
                      skin/kidney diseases. In conclusion, although CD4(+)FOXP3(+)
                      T cell frequencies in the inflamed tissues of SLE patients
                      were comparable to other inflammatory diseases, distinct T
                      cell subpopulations appeared misbalanced in PB of patients
                      with active SLE. Here, cells phenotypically resembling
                      activated T cells, but not Tregs, were increased compared to
                      patients with inactive SLE. Within Tregs of patients with
                      active SLE, markers related to Treg function and homing were
                      altered.},
      cin          = {D030 / G130},
      ddc          = {610},
      cid          = {I:(DE-He78)D030-20160331 / I:(DE-He78)G130-20160331},
      pnm          = {322 - Genetics and Pathophysiology (POF3-322)},
      pid          = {G:(DE-HGF)POF3-322},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28224362},
      doi          = {10.1007/s12026-017-8904-4},
      url          = {https://inrepo02.dkfz.de/record/124251},
}