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@ARTICLE{Galuschka:124256,
      author       = {C. Galuschka$^*$ and R. Proynova$^*$ and B. Roth$^*$ and H.
                      Augustin$^*$ and K. Müller-Decker$^*$},
      title        = {{M}odels in {T}ranslational {O}ncology: {A} {P}ublic
                      {R}esource {D}atabase for {P}reclinical {C}ancer
                      {R}esearch.},
      journal      = {Cancer research},
      volume       = {77},
      number       = {10},
      issn         = {1538-7445},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2017-01152},
      pages        = {2557 - 2563},
      year         = {2017},
      abstract     = {The devastating diseases of human cancer are mimicked in
                      basic and translational cancer research by a steadily
                      increasing number of tumor models, a situation requiring a
                      platform with standardized reports to share model data.
                      Models in Translational Oncology (MiTO) database was
                      developed as a unique Web platform aiming for a
                      comprehensive overview of preclinical models covering
                      genetically engineered organisms, models of transplantation,
                      chemical/physical induction, or spontaneous development,
                      reviewed here. MiTO serves data entry for metastasis
                      profiles and interventions. Moreover, cell lines and animal
                      lines including tool strains can be recorded. Hyperlinks for
                      connection with other databases and file uploads as
                      supplementary information are supported. Several
                      communication tools are offered to facilitate exchange of
                      information. Notably, intellectual property can be protected
                      prior to publication by inventor-defined accessibility of
                      any given model. Data recall is via a highly configurable
                      keyword search. Genome editing is expected to result in
                      changes of the spectrum of model organisms, a reason to open
                      MiTO for species-independent data. Registered users may
                      deposit own model fact sheets (FS). MiTO experts check them
                      for plausibility. Independently, manually curated FS are
                      provided to principle investigators for revision and
                      publication. Importantly, noneditable versions of reviewed
                      FS can be cited in peer-reviewed journals. Cancer Res;
                      77(10); 2557-63. ©2017 AACR.},
      subtyp        = {Review Article},
      cin          = {A190 / W420 / W310 / G230 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)A190-20160331 / I:(DE-He78)W420-20160331 /
                      I:(DE-He78)W310-20160331 / I:(DE-He78)G230-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28507049},
      doi          = {10.1158/0008-5472.CAN-16-3099},
      url          = {https://inrepo02.dkfz.de/record/124256},
}