%0 Journal Article
%A Jaramillo, S.
%A Benner, A.
%A Krauter, J.
%A Martin, H.
%A Kindler, T.
%A Bentz, M.
%A Salih, H. R.
%A Held, G.
%A Köhne, C-H
%A Götze, K.
%A Lübbert, M.
%A Kündgen, A.
%A Brossart, P.
%A Wattad, M.
%A Salwender, H.
%A Hertenstein, B.
%A Nachbaur, D.
%A Wulf, G.
%A Horst, H-A
%A Kirchen, H.
%A Fiedler, W.
%A Raghavachar, A.
%A Russ, G.
%A Kremers, S.
%A Koller, E.
%A Runde, V.
%A Heil, G.
%A Weber, D.
%A Göhring, G.
%A Döhner, K.
%A Ganser, A.
%A Döhner, H.
%A Schlenk, Richard
%T Condensed versus standard schedule of high-dose cytarabine consolidation therapy with pegfilgrastim growth factor support in acute myeloid leukemia.
%J Blood cancer journal
%V 7
%N 5
%@ 2044-5385
%C London [u.a.]
%I Nature Publishing Group
%M DKFZ-2017-01183
%P e564 -
%D 2017
%X The aim of this cohort study was to compare a condensed schedule of consolidation therapy with high-dose cytarabine on days 1, 2 and 3 (HDAC-123) with the HDAC schedule given on days 1, 3 and 5 (HDAC-135) as well as to evaluate the prophylactic use of pegfilgrastim after chemotherapy in younger patients with acute myeloid leukemia in first complete remission. One hundred and seventy-six patients were treated with HDAC-135 and 392 patients with HDAC-123 with prophylactic pegfilgrastim at days 10 and 8, respectively, in the AMLSG 07-04 and the German AML Intergroup protocol. Time from start to chemotherapy until hematologic recovery with white blood cells >1.0 G/l and neutrophils >0.5 G/l was in median 4 days shorter in patients receiving HDAC-123 compared with HDAC-135 (P<0.0001, each), and further reduced by 2 days (P<0.0001) by pegfilgrastim. Rates of infections were reduced by HDAC-123 (P<0.0001) and pegfilgrastim (P=0.002). Days in hospital and platelet transfusions were significantly reduced by HDAC-123 compared with HDAC-135. Survival was neither affected by HDAC-123 versus HDAC-135 nor by pegfilgrastim. In conclusion, consolidation therapy with HDAC-123 leads to faster hematologic recovery and less infections, platelet transfusions as well as days in hospital without affecting survival.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28548643
%R 10.1038/bcj.2017.45
%U https://inrepo02.dkfz.de/record/124287