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@ARTICLE{Huse:124362,
      author       = {J. T. Huse and M. Snuderl and D. Jones$^*$ and C. D.
                      Brathwaite and N. Altman and E. Lavi and R. Saffery and A.
                      Sexton-Oates and I. Blumcke and D. Capper$^*$ and M. A.
                      Karajannis and R. Benayed and L. Chavez$^*$ and C. Thomas
                      and J. Serrano and L. Borsu and M. Ladanyi and M. K.
                      Rosenblum},
      title        = {{P}olymorphous low-grade neuroepithelial tumor of the young
                      ({PLNTY}): an epileptogenic neoplasm with
                      oligodendroglioma-like components, aberrant {CD}34
                      expression, and genetic alterations involving the {MAP}
                      kinase pathway.},
      journal      = {Acta neuropathologica},
      volume       = {133},
      number       = {3},
      issn         = {1432-0533},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {DKFZ-2017-01241},
      pages        = {417 - 429},
      year         = {2017},
      abstract     = {Epileptogenic tumors affecting children and young adults
                      are a morphologically diverse collection of neuroepithelial
                      neoplasms that, as a group, exhibit varying levels of glial
                      and/or neuronal differentiation. Recent advances in
                      molecular profiling technology, including comprehensive DNA
                      sequencing and methylation analysis, have enabled the
                      application of more precise and biologically relevant
                      classification schemes to these tumors. In this report, we
                      describe a morphologically and molecularly distinct
                      epileptogenic neoplasm, the polymorphous low-grade
                      neuroepithelial tumor of the young (PLNTY), which likely
                      accounts for a sizable portion of oligodendroglioma-like
                      tumors affecting the pediatric population. Characteristic
                      microscopic findings most notably include infiltrative
                      growth, the invariable presence of oligodendroglioma-like
                      cellular components, and intense immunolabeling for cluster
                      of differentiation 34 (CD34). Moreover, integrative
                      molecular profiling reveals a distinct DNA methylation
                      signature for PLNTYs, along with frequent genetic
                      abnormalities involving either B-Raf proto-oncogene (BRAF)
                      or fibroblast growth factor receptors 2 and 3 (FGFR2,
                      FGFR3). These findings suggest that PLNTY represents a
                      distinct biological entity within the larger spectrum of
                      pediatric, low-grade neuroepithelial tumors.},
      cin          = {B062 / G380},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)G380-20160331},
      pnm          = {319H - Addenda (POF3-319H)},
      pid          = {G:(DE-HGF)POF3-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27812792},
      pmc          = {pmc:PMC5325850},
      doi          = {10.1007/s00401-016-1639-9},
      url          = {https://inrepo02.dkfz.de/record/124362},
}