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000124366 0247_ $$2doi$$a10.1093/neuonc/now101
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000124366 037__ $$aDKFZ-2017-01245
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000124366 1001_ $$aJones, Chris$$b0
000124366 245__ $$aPediatric high-grade glioma: biologically and clinically in need of new thinking.
000124366 260__ $$aOxford$$bOxford Univ. Press$$c2017
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000124366 520__ $$aHigh-grade gliomas in children are different from those that arise in adults. Recent collaborative molecular analyses of these rare cancers have revealed previously unappreciated connections among chromatin regulation, developmental signaling, and tumorigenesis. As we begin to unravel the unique developmental origins and distinct biological drivers of this heterogeneous group of tumors, clinical trials need to keep pace. It is important to avoid therapeutic strategies developed purely using data obtained from studies on adult glioblastoma. This approach has resulted in repetitive trials and ineffective treatments being applied to these children, with limited improvement in clinical outcome. The authors of this perspective, comprising biology and clinical expertise in the disease, recently convened to discuss the most effective ways to translate the emerging molecular insights into patient benefit. This article reviews our current understanding of pediatric high-grade glioma and suggests approaches for innovative clinical management.
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000124366 7001_ $$aKarajannis, Matthias A$$b1
000124366 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David$$b2$$udkfz
000124366 7001_ $$aKieran, Mark W$$b3
000124366 7001_ $$aMonje, Michelle$$b4
000124366 7001_ $$aBaker, Suzanne J$$b5
000124366 7001_ $$aBecher, Oren J$$b6
000124366 7001_ $$aCho, Yoon-Jae$$b7
000124366 7001_ $$aGupta, Nalin$$b8
000124366 7001_ $$aHawkins, Cynthia$$b9
000124366 7001_ $$aHargrave, Darren$$b10
000124366 7001_ $$aHaas-Kogan, Daphne A$$b11
000124366 7001_ $$aJabado, Nada$$b12
000124366 7001_ $$aLi, Xiao-Nan$$b13
000124366 7001_ $$aMueller, Sabine$$b14
000124366 7001_ $$aNicolaides, Theo$$b15
000124366 7001_ $$aPacker, Roger J$$b16
000124366 7001_ $$aPersson, Anders I$$b17
000124366 7001_ $$aPhillips, Joanna J$$b18
000124366 7001_ $$aSimonds, Erin F$$b19
000124366 7001_ $$aStafford, James M$$b20
000124366 7001_ $$aTang, Yujie$$b21
000124366 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b22$$udkfz
000124366 7001_ $$aWeiss, William A$$b23
000124366 773__ $$0PERI:(DE-600)2094060-9$$a10.1093/neuonc/now101$$gVol. 19, no. 2, p. now101 -$$n2$$p153-161$$tNeuro-Oncology$$v19$$x1523-5866$$y2017
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