TY  - JOUR
AU  - Jones, Chris
AU  - Karajannis, Matthias A
AU  - Jones, David
AU  - Kieran, Mark W
AU  - Monje, Michelle
AU  - Baker, Suzanne J
AU  - Becher, Oren J
AU  - Cho, Yoon-Jae
AU  - Gupta, Nalin
AU  - Hawkins, Cynthia
AU  - Hargrave, Darren
AU  - Haas-Kogan, Daphne A
AU  - Jabado, Nada
AU  - Li, Xiao-Nan
AU  - Mueller, Sabine
AU  - Nicolaides, Theo
AU  - Packer, Roger J
AU  - Persson, Anders I
AU  - Phillips, Joanna J
AU  - Simonds, Erin F
AU  - Stafford, James M
AU  - Tang, Yujie
AU  - Pfister, Stefan
AU  - Weiss, William A
TI  - Pediatric high-grade glioma: biologically and clinically in need of new thinking.
JO  - Neuro-Oncology
VL  - 19
IS  - 2
SN  - 1523-5866
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2017-01245
SP  - 153-161
PY  - 2017
AB  - High-grade gliomas in children are different from those that arise in adults. Recent collaborative molecular analyses of these rare cancers have revealed previously unappreciated connections among chromatin regulation, developmental signaling, and tumorigenesis. As we begin to unravel the unique developmental origins and distinct biological drivers of this heterogeneous group of tumors, clinical trials need to keep pace. It is important to avoid therapeutic strategies developed purely using data obtained from studies on adult glioblastoma. This approach has resulted in repetitive trials and ineffective treatments being applied to these children, with limited improvement in clinical outcome. The authors of this perspective, comprising biology and clinical expertise in the disease, recently convened to discuss the most effective ways to translate the emerging molecular insights into patient benefit. This article reviews our current understanding of pediatric high-grade glioma and suggests approaches for innovative clinical management.
LB  - PUB:(DE-HGF)16
C6  - pmid:27282398
C2  - pmc:PMC5464243
DO  - DOI:10.1093/neuonc/now101
UR  - https://inrepo02.dkfz.de/record/124366
ER  -