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@ARTICLE{Tsai:124412,
      author       = {M.-H. Tsai$^*$ and X. Lin$^*$ and A. Shumilov$^*$ and K.
                      Bernhardt$^*$ and R. Feederle$^*$ and R. Poirey$^*$ and A.
                      Kopp-Schneider$^*$ and B. Pereira and R. Almeida and H.-J.
                      Delecluse$^*$},
      title        = {{T}he biological properties of different {E}pstein-{B}arr
                      virus strains explain their association with various types
                      of cancers.},
      journal      = {OncoTarget},
      volume       = {8},
      number       = {6},
      issn         = {1949-2553},
      address      = {[S.l.]},
      publisher    = {Impact Journals LLC},
      reportid     = {DKFZ-2017-01291},
      pages        = {10238-10254},
      year         = {2017},
      abstract     = {The Epstein-Barr virus (EBV) is etiologically associated
                      with the development of multiple types of tumors, but it is
                      unclear whether this diversity is due to infection with
                      different EBV strains. We report a comparative
                      characterization of SNU719, GP202, and YCCEL1, three EBV
                      strains that were isolated from gastric carcinomas, M81, a
                      virus isolated in a nasopharyngeal carcinoma and several
                      well-characterized laboratory type A strains. We found that
                      B95-8, Akata and GP202 induced cell growth more efficiently
                      than YCCEL1, SNU719 and M81 and this correlated positively
                      with the expression levels of the viral BHRF1 miRNAs. In
                      infected B cells, all strains except Akata and B95-8 induced
                      lytic replication, a risk factor for carcinoma development,
                      although less efficiently than M81. The panel of viruses
                      induced tumors in immunocompromised mice with variable speed
                      and efficacy that did not strictly mirror their in vitro
                      characteristics, suggesting that additional parameters play
                      an important role. We found that YCCEL1 and M81 infected
                      primary epithelial cells, gastric carcinoma cells and
                      gastric spheroids more efficiently than Akata or B95-8.
                      Reciprocally, Akata and B95-8 had a stronger tropism for B
                      cells than YCCEL1 or M81. These data suggest that different
                      EBV strains will induce the development of lymphoid tumors
                      with variable efficacy in immunocompromised patients and
                      that there is a parallel between the cell tropism of the
                      viral strains and the lineage of the tumors they induce.
                      Thus, EBV strains can be endowed with properties that will
                      influence their transforming abilities and the type of tumor
                      they induce.},
      cin          = {F100 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)F100-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {316 - Infections and cancer (POF3-316)},
      pid          = {G:(DE-HGF)POF3-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28052012},
      pmc          = {pmc:PMC5354655},
      doi          = {10.18632/oncotarget.14380},
      url          = {https://inrepo02.dkfz.de/record/124412},
}