%0 Journal Article
%A Schuenke, Patrick
%A Koehler, Christina
%A Korzowski, Andreas
%A Windschuh, Johannes
%A Bachert, Peter
%A Ladd, Mark
%A Mundiyanapurath, Sibu
%A Paech, Daniel
%A Bickelhaupt, Sebastian
%A Bonekamp, David
%A Schlemmer, Heinz-Peter
%A Radbruch, Alexander
%A Zaiss, Moritz
%T Adiabatically prepared spin-lock approach for T1ρ-based dynamic glucose enhanced MRI at ultrahigh fields.
%J Magnetic resonance in medicine
%V 78
%N 1
%@ 0740-3194
%C New York, NY [u.a.]
%I Wiley-Liss
%M DKFZ-2017-01305
%P 215 - 225
%D 2017
%X Chemical exchange sensitive spin-lock and related techniques allow to observe the uptake of administered D-glucose in vivo. The exchange-weighting increases with the magnetic field strength, but inhomogeneities in the radiofrequency (RF) field at ultrahigh field whole-body scanners lead to artifacts in conventional spin-lock experiments. Thus, our aim was the development of an adiabatically prepared T1ρ -based imaging sequence applicable to studies of glucose metabolism in tumor patients at ultrahigh field strengths.An adiabatically prepared on-resonant spin-lock approach was realized at a 7 Tesla whole-body scanner and compared with conventional spin-lock. The insensitivity to RF field inhomogeneities as well as the chemical exchange sensitivity of the approach was investigated in simulations, model solutions and in the human brain.The suggested spin-lock approach was shown to be feasible for in vivo application at ultrahigh field whole-body scanners and showed substantially improved image quality compared with conventional spin-lock. The sensitivity of the presented method to glucose was verified in model solutions and a glucose contrast was observed in a glioblastoma patient after intravenous administration of glucose solution.An adiabatically prepared spin-lock preparation was presented that enables a homogeneous and chemical exchange sensitive T1ρ -based imaging at ultra-high field whole-body scanners, e.g., for T1ρ -based dynamic glucose enhanced MRI. Magn Reson Med 78:215-225, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:27521026
%R 10.1002/mrm.26370
%U https://inrepo02.dkfz.de/record/124428