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000124428 1001_ $$0P:(DE-HGF)0$$aSchuenke, Patrick$$b0$$eFirst author
000124428 245__ $$aAdiabatically prepared spin-lock approach for T1ρ-based dynamic glucose enhanced MRI at ultrahigh fields.
000124428 260__ $$aNew York, NY [u.a.]$$bWiley-Liss$$c2017
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000124428 520__ $$aChemical exchange sensitive spin-lock and related techniques allow to observe the uptake of administered D-glucose in vivo. The exchange-weighting increases with the magnetic field strength, but inhomogeneities in the radiofrequency (RF) field at ultrahigh field whole-body scanners lead to artifacts in conventional spin-lock experiments. Thus, our aim was the development of an adiabatically prepared T1ρ -based imaging sequence applicable to studies of glucose metabolism in tumor patients at ultrahigh field strengths.An adiabatically prepared on-resonant spin-lock approach was realized at a 7 Tesla whole-body scanner and compared with conventional spin-lock. The insensitivity to RF field inhomogeneities as well as the chemical exchange sensitivity of the approach was investigated in simulations, model solutions and in the human brain.The suggested spin-lock approach was shown to be feasible for in vivo application at ultrahigh field whole-body scanners and showed substantially improved image quality compared with conventional spin-lock. The sensitivity of the presented method to glucose was verified in model solutions and a glucose contrast was observed in a glioblastoma patient after intravenous administration of glucose solution.An adiabatically prepared spin-lock preparation was presented that enables a homogeneous and chemical exchange sensitive T1ρ -based imaging at ultra-high field whole-body scanners, e.g., for T1ρ -based dynamic glucose enhanced MRI. Magn Reson Med 78:215-225, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
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000124428 7001_ $$0P:(DE-HGF)0$$aKoehler, Christina$$b1
000124428 7001_ $$0P:(DE-He78)577a5c61f44b8023e229610afbc7cd4e$$aKorzowski, Andreas$$b2$$udkfz
000124428 7001_ $$0P:(DE-He78)98b696ed60c17f4ddd0da9fdc20a2492$$aWindschuh, Johannes$$b3$$udkfz
000124428 7001_ $$0P:(DE-He78)29b2f01310f7022916255ddba2750f9b$$aBachert, Peter$$b4$$udkfz
000124428 7001_ $$0P:(DE-He78)022611a2317e4de40fd912e0a72293a8$$aLadd, Mark$$b5$$udkfz
000124428 7001_ $$aMundiyanapurath, Sibu$$b6
000124428 7001_ $$0P:(DE-He78)c6e31fb8f19e185e254174554a0cccfc$$aPaech, Daniel$$b7$$udkfz
000124428 7001_ $$0P:(DE-He78)d2d971750bce6217eb90fff9b01e61f9$$aBickelhaupt, Sebastian$$b8$$udkfz
000124428 7001_ $$0P:(DE-He78)ea098e4d78abeb63afaf8c25ec6d6d93$$aBonekamp, David$$b9$$udkfz
000124428 7001_ $$0P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec$$aSchlemmer, Heinz-Peter$$b10$$udkfz
000124428 7001_ $$0P:(DE-He78)77588f5b9413339755a66e739d316c7d$$aRadbruch, Alexander$$b11$$udkfz
000124428 7001_ $$0P:(DE-He78)db923d831c5fe9b5e8fab7794dd45c44$$aZaiss, Moritz$$b12$$eLast author$$udkfz
000124428 773__ $$0PERI:(DE-600)1493786-4$$a10.1002/mrm.26370$$gVol. 78, no. 1, p. 215 - 225$$n1$$p215 - 225$$tMagnetic resonance in medicine$$v78$$x0740-3194$$y2017
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