TY  - JOUR
AU  - Schuenke, Patrick
AU  - Koehler, Christina
AU  - Korzowski, Andreas
AU  - Windschuh, Johannes
AU  - Bachert, Peter
AU  - Ladd, Mark
AU  - Mundiyanapurath, Sibu
AU  - Paech, Daniel
AU  - Bickelhaupt, Sebastian
AU  - Bonekamp, David
AU  - Schlemmer, Heinz-Peter
AU  - Radbruch, Alexander
AU  - Zaiss, Moritz
TI  - Adiabatically prepared spin-lock approach for T1ρ-based dynamic glucose enhanced MRI at ultrahigh fields.
JO  - Magnetic resonance in medicine
VL  - 78
IS  - 1
SN  - 0740-3194
CY  - New York, NY [u.a.]
PB  - Wiley-Liss
M1  - DKFZ-2017-01305
SP  - 215 - 225
PY  - 2017
AB  - Chemical exchange sensitive spin-lock and related techniques allow to observe the uptake of administered D-glucose in vivo. The exchange-weighting increases with the magnetic field strength, but inhomogeneities in the radiofrequency (RF) field at ultrahigh field whole-body scanners lead to artifacts in conventional spin-lock experiments. Thus, our aim was the development of an adiabatically prepared T1ρ -based imaging sequence applicable to studies of glucose metabolism in tumor patients at ultrahigh field strengths.An adiabatically prepared on-resonant spin-lock approach was realized at a 7 Tesla whole-body scanner and compared with conventional spin-lock. The insensitivity to RF field inhomogeneities as well as the chemical exchange sensitivity of the approach was investigated in simulations, model solutions and in the human brain.The suggested spin-lock approach was shown to be feasible for in vivo application at ultrahigh field whole-body scanners and showed substantially improved image quality compared with conventional spin-lock. The sensitivity of the presented method to glucose was verified in model solutions and a glucose contrast was observed in a glioblastoma patient after intravenous administration of glucose solution.An adiabatically prepared spin-lock preparation was presented that enables a homogeneous and chemical exchange sensitive T1ρ -based imaging at ultra-high field whole-body scanners, e.g., for T1ρ -based dynamic glucose enhanced MRI. Magn Reson Med 78:215-225, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
LB  - PUB:(DE-HGF)16
C6  - pmid:27521026
DO  - DOI:10.1002/mrm.26370
UR  - https://inrepo02.dkfz.de/record/124428
ER  -