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@ARTICLE{Schuenke:124428,
      author       = {P. Schuenke$^*$ and C. Koehler$^*$ and A. Korzowski$^*$ and
                      J. Windschuh$^*$ and P. Bachert$^*$ and M. Ladd$^*$ and S.
                      Mundiyanapurath and D. Paech$^*$ and S. Bickelhaupt$^*$ and
                      D. Bonekamp$^*$ and H.-P. Schlemmer$^*$ and A. Radbruch$^*$
                      and M. Zaiss$^*$},
      title        = {{A}diabatically prepared spin-lock approach for
                      {T}1ρ-based dynamic glucose enhanced {MRI} at ultrahigh
                      fields.},
      journal      = {Magnetic resonance in medicine},
      volume       = {78},
      number       = {1},
      issn         = {0740-3194},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2017-01305},
      pages        = {215 - 225},
      year         = {2017},
      abstract     = {Chemical exchange sensitive spin-lock and related
                      techniques allow to observe the uptake of administered
                      D-glucose in vivo. The exchange-weighting increases with the
                      magnetic field strength, but inhomogeneities in the
                      radiofrequency (RF) field at ultrahigh field whole-body
                      scanners lead to artifacts in conventional spin-lock
                      experiments. Thus, our aim was the development of an
                      adiabatically prepared T1ρ -based imaging sequence
                      applicable to studies of glucose metabolism in tumor
                      patients at ultrahigh field strengths.An adiabatically
                      prepared on-resonant spin-lock approach was realized at a 7
                      Tesla whole-body scanner and compared with conventional
                      spin-lock. The insensitivity to RF field inhomogeneities as
                      well as the chemical exchange sensitivity of the approach
                      was investigated in simulations, model solutions and in the
                      human brain.The suggested spin-lock approach was shown to be
                      feasible for in vivo application at ultrahigh field
                      whole-body scanners and showed substantially improved image
                      quality compared with conventional spin-lock. The
                      sensitivity of the presented method to glucose was verified
                      in model solutions and a glucose contrast was observed in a
                      glioblastoma patient after intravenous administration of
                      glucose solution.An adiabatically prepared spin-lock
                      preparation was presented that enables a homogeneous and
                      chemical exchange sensitive T1ρ -based imaging at
                      ultra-high field whole-body scanners, e.g., for T1ρ -based
                      dynamic glucose enhanced MRI. Magn Reson Med 78:215-225,
                      2017. © 2016 International Society for Magnetic Resonance
                      in Medicine.},
      cin          = {E020 / E010},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331 / I:(DE-He78)E010-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27521026},
      doi          = {10.1002/mrm.26370},
      url          = {https://inrepo02.dkfz.de/record/124428},
}